{
  "abstract": "Purpose: To investigate longitudinal changes of Na[18F]Fluoride uptake in the axial skeleton of patients with radiographic axial spondyloarthritis (r-axSpA) during biological treatment, focusing on r-axSpA and degenerative (D) lesions.\n\nMethods: 20 active r-axSpA patients were included. Na[18F]Fluoride Positron Emission Tomography / Computed Tomography (PET/CT) scans were performed prior to, as well as 12 and 52 weeks after starting biological therapy. PET-positive lesions in the axial skeleton were scored and classified by two blinded readers. Quantitative Na[18F]Fluoride uptake was assessed by determination of standardized uptake values (SUV) corrected for individual integrated whole blood activity concentration (SUVAUC).\n\nResults: A total of 276 lesions with visual Na[18F]Fluoride uptake were detected, of which 98 (36%) were defined as r-axSpA and 46 (17%) as D. The total number of r-axSpA lesions decreased from 98 at baseline to 67 at week 12 (-32%) and to 55 at week 52 (-18%), while the number of D lesions remained stable over time. The majority of r-axSpA lesions were observed in the thoracic spine (84%), while the majority of D lesions were observed in the lumbar spine (48%). Quantitatively, 84% and 88% of the r-axSpA lesions showed a decrease of Na[18F]Fluoride uptake between baseline and 12 and 52 weeks, respectively. In contrast, most D lesions either showed an increase or mild decrease between baseline and follow-up.\n\nConclusion: Na[18F]Fluoride uptake in visually classified r-axSpA and D lesions in r-axSpA patients on PET/CT demonstrated a striking different change in both the number of r-axSpA lesions and quantitative tracer uptake herein versus D lesions while on biological treatment.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00259-026-08178-6.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Rheumatology & Clinical Immunology, Amsterdam UMC, Amsterdam, The Netherlands",
    "Department of Radiology & Nuclear Medicine, Amsterdam UMC, Amsterdam, The Netherlands",
    "Department of Radiology & Nuclear Medicine, OLVG, Amsterdam, The Netherlands",
    "UCB Biopharma SRL, Brussels, Belgium",
    "UCB Pharma, Slough, United Kingdom"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jerney de Jongh"
    },
    {
      "affs": [
        0
      ],
      "name": "Sam Groothuizen",
      "orcid": "0009-0007-6097-8886"
    },
    {
      "affs": [
        1
      ],
      "name": "Gerben J.C. Zwezerijnen",
      "orcid": "0000-0002-9571-9362"
    },
    {
      "affs": [
        1
      ],
      "name": "Robert Hemke",
      "orcid": "0000-0002-0826-302X"
    },
    {
      "affs": [
        2
      ],
      "name": "Tom Doorschodt"
    },
    {
      "affs": [
        3
      ],
      "name": "Ralph Paul Maguire",
      "orcid": "0000-0003-3937-6622"
    },
    {
      "affs": [
        4
      ],
      "name": "Tom Vaux"
    },
    {
      "affs": [
        0
      ],
      "name": "Conny J. van der Laken",
      "orcid": "0000-0002-9865-6213"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/88cafj9ra4x4d.bib",
  "cited_by": 0,
  "doi": "10.1007/s00259-026-08178-6",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13727908/",
  "id": "88cafj9ra4x4d",
  "issns": [
    "1619-7070",
    "1619-7089"
  ],
  "landing_url": "https://doi.org/10.1007/s00259-026-08178-6",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2745|Spondyloarthritis Studies and Treatments"
    ]
  ],
  "openalex": "W7220910617",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00259-026-08178-6.pdf",
  "pmcid": "PMC13727908",
  "pmid": "42850434",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/88cafj9ra4x4d.ris",
  "sources": [
    {
      "first_seen": "2026-11-06T12:23:42Z",
      "native_id": "PMC13727908",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00259-026-08178-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "Differentiation of axial spondyloarthritis-related lesions from degenerative lesions on Na[18F]Fluoride PET/CT in a longitudinal dataset of patients with radiographic axial spondyloarthritis",
  "title_text": "Differentiation of axial spondyloarthritis-related lesions from degenerative lesions on Na[18F]Fluoride PET/CT in a longitudinal dataset of patients with radiographic axial spondyloarthritis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:00Z",
  "url": "https://research.draconitic.com/paper/88cafj9ra4x4d",
  "venue": "European Journal of Nuclear Medicine and Molecular Imaging",
  "versions": []
}