{
  "abstract": "Angiotensin II (Ang II) plays crucial roles in renal dysfunction, fibrotic changes, apoptosis, and oxidative stress. CIRBP, a cold-inducible RNA-binding protein, functions to maintain cellular homeostasis. However, its role in renal damage elicited by Ang II remains unclear. Here, we investigated the mechanisms through which Cirbp overexpression alleviates renal damage caused by Ang II, and Cirbp deletion induces basal renal injury. Transcriptomic analysis identified the involvement of Cirbp in hypertension-related renal injury. Across the animal and cell models, Cirbp overexpression attenuated Ang II-induced renal dysfunction, fibrosis, apoptosis, and inflammation, whereas Cirbp deficiency aggravated basal injury and increased renal susceptibility to injury. CIRBP activated the KEAP1-NRF2 antioxidant pathway to mitigate redox stress. This renoprotective effect was reversed following the application of the NRF2 inhibitor ML385, but was resumed by the NRF2 agonist RA839. Together, CIRBP modulates redox imbalance during Ang II-mediated renal damage through KEAP1-NRF2 signaling.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China.",
    "Department of Emergency The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University Huai'an China.",
    "Department of Cardiology The Affiliated Suzhou Hospital with Nanjing Medical University Suzhou Municipal Hospital Gusu School of Nanjing Medical University Suzhou China.",
    "Jiangsu Province Hospital Nanjing China.",
    "Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and Rehabilitation Nanjing University of Chinese Medicine Nanjing China.",
    "Department of Cardiology Shengli Clinical Medical College of Fujian Medical University Fujian Provincial Hospital Fuzhou University Affiliated Provincial Hospital Fuzhou China.",
    "Fujian Provincial Key Laboratory of Cardiovascular Disease Fujian Cardiovascular Institute Fujian Clinical Medical Research Center for Cardiovascular Diseases Fuzhou China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yue Zhang",
      "orcid": "0009-0005-3505-9525"
    },
    {
      "affs": [
        0
      ],
      "name": "Qilin Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Man Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongxu Hua"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Yanhui Sheng",
      "orcid": "0000-0001-5109-8704"
    },
    {
      "affs": [
        4
      ],
      "name": "Lei Wang",
      "orcid": "0000-0002-9515-3637"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Peng Li",
      "orcid": "0000-0003-0365-2103"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/88sd1hf2r0ne4.bib",
  "cited_by": 0,
  "doi": "10.1002/smmd.70062",
  "fulltext_url": "https://europepmc.org/articles/PMC13744398",
  "id": "88sd1hf2r0ne4",
  "issns": [
    "2751-1863",
    "2751-1871"
  ],
  "landing_url": "https://europepmc.org/article/MED/42999923",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Renin-Angiotensin System Studies"
    ]
  ],
  "openalex": "W7225467879",
  "pdf_url": "https://europepmc.org/articles/PMC13744398?pdf=render",
  "pmcid": "PMC13744398",
  "pmid": "42999923",
  "published": "2026-11-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/88sd1hf2r0ne4.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42999923",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42999923"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Renin-Angiotensin System Studies",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Cold-Inducible RNA-Binding Protein Alleviates Hypertensive Renal Injury Through the KEAP1-NRF2 Pathway.",
  "title_text": "Cold-Inducible RNA-Binding Protein Alleviates Hypertensive Renal Injury Through the KEAP1-NRF2 Pathway.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/88sd1hf2r0ne4",
  "venue": "Smart medicine",
  "versions": []
}