{
  "abstract": "A growing body of evidence suggests that aging is not simply the accumulation of damage, but a systemic progression of increasing entropy across biological scales. Synthesizing concepts from thermodynamics and information theory, we outline a tentative three-stage entropy model of the lifespan: order-building development, homeostatic adulthood, and disorder-dominant aging. Within this model, we attempt to reframe the established hallmarks of aging as interconnected nodes in an entropy-centered network and detail the multiscale manifestations of disorder from molecules to systems. To quantify this trajectory, we introduce a Multiscale Entropic Aging Index (MEAI) as a proof-of-concept conceptual framework, designed to integrate measurements of disorder across biological levels. This framework seeks to offer a potential unifying, quantitative language for aging research and suggests that entropy reduction could serve as a testable mechanism underlying interventions, laying a principled foundation for the future development of biomarkers and rejuvenative strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Aging Biomarker Consortium (ABC) , Beijing 100101,",
    "School of Life Sciences, Jilin University , Changchun 130012,",
    "Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101,",
    "State Key Laboratory of Organ Regeneration and Reconstruction, Human Organ Physiopathology Emulation System, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101,",
    "University of Chinese Academy of Sciences , Beijing 100049,",
    "Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University , Beijing 100053,",
    "China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101,",
    "Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University , Beijing 100029,",
    "Altos Labs San Diego Institute of Science , San Diego, CA 94065,",
    "Salk Institute for Biological Studies , La Jolla, CA 92037,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zeming Wu",
      "orcid": "0000-0001-8535-3427"
    },
    {
      "affs": [
        0,
        2,
        3,
        4
      ],
      "name": "Shuai Ma"
    },
    {
      "affs": [
        5,
        0
      ],
      "name": "Si Wang",
      "orcid": "0000-0002-1079-089X"
    },
    {
      "affs": [
        0,
        2,
        3,
        4
      ],
      "name": "Moshi Song",
      "orcid": "0000-0001-9929-8975"
    },
    {
      "affs": [
        0,
        6,
        4
      ],
      "name": "Weiqi Zhang",
      "orcid": "0000-0002-8885-5104"
    },
    {
      "affs": [
        0,
        2,
        7,
        3,
        4
      ],
      "name": "Jing Qu",
      "orcid": "0000-0002-3988-5067"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Juan Carlos Izpisúa Belmonte",
      "orcid": "0000-0003-0557-8875"
    },
    {
      "affs": [
        0,
        2,
        3,
        4
      ],
      "name": "Guang‐Hui Liu",
      "orcid": "0000-0001-9289-8177"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/891qqyztx5pkz.bib",
  "cited_by": 11,
  "doi": "10.1093/lifemedi/lnag020",
  "fulltext_url": null,
  "id": "891qqyztx5pkz",
  "issns": [
    "2755-1733"
  ],
  "landing_url": "https://doi.org/10.1093/lifemedi/lnag020",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
  ],
  "openalex": "W7162427714",
  "pdf_url": null,
  "pmcid": "PMC13319325",
  "pmid": "42388853",
  "published": "2026-05-23",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/891qqyztx5pkz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:46Z",
      "native_id": "W7162427714",
      "source": "openalex",
      "url": "https://doi.org/10.1093/lifemedi/lnag020"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "The entropic view of aging: from thermodynamics to biology",
  "title_text": "The entropic view of aging: from thermodynamics to biology",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:07Z",
  "url": "https://research.draconitic.com/paper/891qqyztx5pkz",
  "venue": "Life Medicine",
  "versions": []
}