{
  "abstract": "Objectives: To compare the remineralization potential of chitosan-fluoride-doped mesoporous silica nanoparticles (FMSN) hydrogel and casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) paste on artificially demineralized enamel of primary teeth. Materials and Methods: Thirty extracted primary central incisors were randomly allocated into two groups (n = 15). Group CH received Chitosan-FMSN hydrogel, and Group GC received CPP-ACPF paste. The remineralizing agents were applied twice daily for 3 months. Remineralization was assessed using DIAGNOdent®, while elemental composition and surface morphology were evaluated using energy-dispersive X-ray spectroscopy and field emission scanning electron microscopy. Statistical Analysis: Intergroup comparisons were performed using an independent Student’s t-test, and intragroup comparisons were performed using a paired t-test. Statistical significance was set at P < 0.05. Results: The CPP-ACPF group showed a significant increase in calcium content from 55.47% to 67.96% (P = 0.001), whereas the Chitosan-FMSN group showed a decrease from 53.59% to 42.37% (P = 0.095). The Ca/P ratio increased from 1.25 to 2.62 in the CPP-ACPF group and decreased from 1.16 to 1.04 in the Chitosan-FMSN group, with a significant intergroup difference at three months (P = 0.003). DIAGNOdent® values decreased from 10.66 to 2.40 in the CPP-ACPF group and from 10.06 to 4.26 in the Chitosan-FMSN group. FE-SEM demonstrated greater surface mineral coverage in the CPP-ACPF group. Conclusions: Under the conditions of this in vitro study, CPP-ACPF demonstrated greater remineralization-associated changes than Chitosan-FMSN hydrogel in primary enamel.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "N. K. Suma"
    },
    {
      "name": "M.N.Shwetha"
    },
    {
      "name": "Rajeev J. Mudakavi"
    },
    {
      "name": "B. V. Basavaraj"
    },
    {
      "name": "S. Nikitha"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/89dwq26trnmfz.bib",
  "cited_by": 0,
  "doi": "10.4103/jisppd.jisppd_343_26",
  "fulltext_url": "https://www.ovid.com/jnls/pedprevden/fulltext/10.4103/jisppd.jisppd_343_26~comparative-evaluation-of-the-remineralization-potential-of",
  "id": "89dwq26trnmfz",
  "issns": [
    "0970-4388",
    "1998-3905"
  ],
  "landing_url": "https://doi.org/10.4103/jisppd.jisppd_343_26",
  "language": "en",
  "licence": "CC-BY-NC-SA",
  "licence_label": "CC BY-NC-SA",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RK1-715"
    ],
    [
      "openalex",
      "3506|Dental Health and Care Utilization"
    ]
  ],
  "openalex": "W7214054639",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Wolters Kluwer Medknow Publications",
  "ris": "https://research.draconitic.com/paper/89dwq26trnmfz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:52Z",
      "native_id": "260f1dd1d4fa4b46847b2878edc8882d",
      "source": "doaj",
      "url": "https://doi.org/10.4103/jisppd.jisppd_343_26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RK1-715",
      "subfield": "general"
    }
  ],
  "title": "Comparative evaluation of the remineralization potential of chitosan-fluoride-doped mesoporous silica nanoparticles hydrogel and casein phosphopeptide-amorphous calcium phosphate fluoride paste on the enamel of primary teeth: An in vitro study",
  "title_text": "Comparative evaluation of the remineralization potential of chitosan-fluoride-doped mesoporous silica nanoparticles hydrogel and casein phosphopeptide-amorphous calcium phosphate fluoride paste on the enamel of primary teeth: An in vitro study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:52Z",
  "url": "https://research.draconitic.com/paper/89dwq26trnmfz",
  "venue": "Journal of Indian Society of Pedodontics and Preventive Dentistry",
  "versions": []
}