{
  "abstract": "The process of osseointegration for dental implants is complex and can be influenced by localized inflammation. The NF-κB signaling system plays a crucial role in regulating inflammatory responses. This review examines the role of microRNAs (miRNAs) in regulating the NF-κB pathway in inflammatory conditions associated with dental implants, including periodontitis, alveolar bone abnormalities, and estrogen deficiency models. A review of prior research demonstrates that miRNAs, specifically miR-146a, miR-21a-5p, miR-182, and miR-100-5p, modulate NF-κB activation and maintain the balance between osteogenesis and osteoclastogenesis by targeting molecules such as FoxO1, TLR4, and PDCD4. These interactions lead to a reduction in reactive oxygen species, inhibition of pro-inflammatory cytokines (including IL-1β and TNF-α), and an elevation in osteogenic markers (such as Runx2 and ALP). The findings indicate that the miRNA-NF-κB axes can lead to peri-implantitis and implant failure. On the other hand, miRNA-based therapeutics, such as agomirs and antagomirs, might assist in improving osseointegration outcomes. This study highlights the importance of miRNAs in modulating NF-κB inflammation for the effectiveness of dental implants and suggests avenues for further research.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran",
    "Faculty of Dentistry, Dental Surgery Shahid beheshti University of Medical science, ,Tehran, Iran.",
    "International Dentist Program, School of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, California, United States of America",
    "Faculty of Dentistry, kermanshah university of medical sciences, Kermanshah, Iran.",
    "Department of Endodontics, Faculty of Dentistry, Shahed University, Tehran, Iran.",
    "Department of Periodontics, Faculty of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.",
    "Department of Periodontology, School of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahwaz, Iran"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ghazal Soleimani"
    },
    {
      "affs": [
        1
      ],
      "name": "Pouria Farahani"
    },
    {
      "affs": [
        2
      ],
      "name": "Ailar Yousefbeigi"
    },
    {
      "affs": [
        3
      ],
      "name": "Diyako Farajpur"
    },
    {
      "affs": [
        4
      ],
      "name": "Paria Amooyan"
    },
    {
      "affs": [
        5
      ],
      "name": "Asieh Mozaffari"
    },
    {
      "affs": [
        6
      ],
      "name": "mina aghabeigi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8a089jvajkhsg.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": null,
  "id": "8a089jvajkhsg",
  "issns": [
    "2251-9637",
    "2251-9645"
  ],
  "landing_url": null,
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD1-999"
    ],
    [
      "lcc",
      "QH426-470"
    ]
  ],
  "openalex": null,
  "pdf_url": "http://ijmcmed.org/article-1-2666-en.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-01",
  "publisher": "Babol University of Medical Sciences",
  "ris": "https://research.draconitic.com/paper/8a089jvajkhsg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:46:47Z",
      "native_id": "26120810499d4dacb59994a692ac2708",
      "source": "doaj",
      "url": null
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QH426-470",
      "subfield": "genetics-genomics"
    },
    {
      "field": "chemistry",
      "origin": "lcc:QD1-999",
      "subfield": "general"
    }
  ],
  "title": "Role of MicroRNAs in regulating NF-kB Inflammatory pathways During Dental Implant Osseointegration",
  "title_text": "Role of MicroRNAs in regulating NF-kB Inflammatory pathways During Dental Implant Osseointegration",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:46:47Z",
  "url": "https://research.draconitic.com/paper/8a089jvajkhsg",
  "venue": "International Journal of Molecular and Cellular Medicine",
  "versions": []
}