{
  "abstract": "Background: IDH-wildtype Glioblastoma is characterized by an aggressive clinical course. This study aimed to evaluate the prognostic value of the H-index, the hemoglobin-albumin-lymphocyte-platelet (HALP) score and the aggregate index of systemic inflammation (AISI). Methods: We retrospectively analyzed 136 patients who underwent frontline chemoradiotherapy. Results: Optimal cut-offs were 20.94 for HALP, 2.29 for H-index, and 989.64 for AISI. A high H-index was associated with shorter overall survival (OS) in univariate analysis (p = 0.007) and showed the highest time-dependent AUC for OS among the three indices. In multivariable Cox models, comorbidities (p = 0.043), subtotal resection (p < 0.001), corticosteroid use (p = 0.040), and a low HALP score (p = 0.012) were associated with poor OS, whereas the associations for a high H-index (p = 0.084) and a high AISI (p = 0.036) did not meet the Bonferroni-adjusted significance threshold. In a sensitivity analysis restricted to patients not receiving corticosteroids (n = 80), H-index-based stratification remained associated with OS (median 14.4 vs. 24.9 months, log-rank p = 0.025), whereas the association for AISI was not retained. Conclusions: The H-index, evaluated here for the first time, and the HALP score may provide complementary prognostic information. Given the retrospective single-center design, the potential influence of corticosteroids, and the data-driven cut-offs, these findings should be regarded as exploratory and require external validation before clinical application.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Oncology, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Türkiye.",
    "Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Havva Yeşil",
      "orcid": "0000-0002-7870-8741"
    },
    {
      "affs": [
        1
      ],
      "name": "Bekir Demirel",
      "orcid": "0009-0004-4600-7790"
    },
    {
      "affs": [
        0
      ],
      "name": "Ercan Gumusburun",
      "orcid": "0000-0001-7426-4410"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8aawana4v82zn.bib",
  "cited_by": 0,
  "doi": "10.3390/curroncol33100604",
  "fulltext_url": "https://europepmc.org/articles/PMC13703143",
  "id": "8aawana4v82zn",
  "issns": [
    "1198-0052",
    "1718-7729"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930171",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Glioma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7221103947",
  "pdf_url": "https://europepmc.org/articles/PMC13703143?pdf=render",
  "pmcid": "PMC13703143",
  "pmid": "42930171",
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8aawana4v82zn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930171",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930171"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Glioma Diagnosis and Treatment",
      "subfield": "human-genetics"
    }
  ],
  "title": "Evaluating the Prognostic Significance of the H-Index and Systemic Inflammatory Parameters in IDH-Wildtype Glioblastoma Survival.",
  "title_text": "Evaluating the Prognostic Significance of the H-Index and Systemic Inflammatory Parameters in IDH-Wildtype Glioblastoma Survival.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/8aawana4v82zn",
  "venue": "Current oncology (Toronto, Ont.)",
  "versions": []
}