{
  "abstract": "Purpose: In East Asians most primary open-angle glaucoma (POAG) occurs at statistically normal intraocular pressure (IOP). We sought plasma proteins linked to POAG through genetic signal not shared with IOP. Methods: We integrated the BioBank Japan POAG GWAS with a Japanese plasma pQTL resource (Nagahama; SomaScan v4) using SMR/HEIDI and colocalization against POAG and IOP datasets, including a Genomic-SEM-derived non-IOP POAG component, adding a symmetric proteome-wide cross-ancestry colocalization, fine-mapping and multi-signal colocalization of the RGMB region, a formal heterogeneity test, and expression mapping in retina and trabecular meshwork. Results: Of 679 plasma proteins, four colocalized with POAG in East Asians only, five in Europeans only, none in both. SMR nominated RGMB as a suggestive risk factor (b_SMR = +0.277; HEIDI P > 0.05; PP4 = 0.684; rs1037599); none survived Bonferroni correction. RGMB did not colocalize with European IOP, a European non-IOP POAG component, or European POAG on the same platform, despite a common, directionally consistent pQTL instrument. Multi-signal colocalization reproduced both the East Asian signal and the European null. The per-allele POAG effect differed between ancestries (Cochran's Q P = 0.0036; I2 = 88%), the better-powered European data excluding an effect of East Asian magnitude. RGMB and its receptors were expressed in trabecular meshwork cells and unchanged by TGF-beta2. Conclusions: This triangulation nominates the RGMB-neogenin-BMP axis as a POAG candidate detected in East Asians but not Europeans, which does not colocalize with IOP-related traits. The findings are exploratory; ancestry-matched replication and functional validation are required.",
  "abstract_shown": true,
  "affiliations": [
    "Ehime university"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "S. OKUNO"
    },
    {
      "name": "S. MIZOUE"
    },
    {
      "name": "K. NAMIGUCHI"
    },
    {
      "name": "M. YUKAWA"
    },
    {
      "name": "A. SHIRAISHI"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8acdzan15vs8a.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.26.26366459",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26366459v1.full",
  "id": "8acdzan15vs8a",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26366459v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "genetic and genomic medicine"
    ],
    [
      "openalex",
      "2731|Glaucoma and retinal disorders"
    ]
  ],
  "openalex": "W7224093550",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26366459v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8acdzan15vs8a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:54Z",
      "native_id": "10.64898/2026.10.26.26366459",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.26.26366459v2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:genetic and genomic medicine",
      "subfield": "human-genetics"
    }
  ],
  "title": "Plasma Proteogenomics Identifies RGMB as a Candidate for Primary Open-Angle Glaucoma Detected Only in East Asians",
  "title_text": "Plasma Proteogenomics Identifies RGMB as a Candidate for Primary Open-Angle Glaucoma Detected Only in East Asians",
  "type": "preprint",
  "updated_at": "2026-10-31T00:20:35Z",
  "url": "https://research.draconitic.com/paper/8acdzan15vs8a",
  "venue": "medRxiv",
  "versions": []
}