{
  "abstract": "Patients with malignant lymphoma receiving anti-CD20 antibody therapy are at high risk of persistent coronavirus disease 2019 (COVID-19), with no established standard treatment. We report three cases of persistent COVID-19 in patients with follicular lymphoma who responded clinically after switching to ensitrelvir following the failure of remdesivir-based treatment. Each patient had multiple relapses and an inadequate response to remdesivir but achieved symptom resolution with ensitrelvir. These cases suggest that switching to an antiviral with a different mechanism of action may be an effective therapeutic strategy for immunocompromised patients when initial antiviral therapies fail.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine Shimane University Faculty of Medicine Izumo Shimane Japan.",
    "Department of Hematology Shimane University Hospital Izumo Japan."
  ],
  "article_type": "case study",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mika Horie",
      "orcid": "0009-0008-6385-7278"
    },
    {
      "affs": [
        0
      ],
      "name": "Tamio Okimoto",
      "orcid": "0000-0001-8295-1296"
    },
    {
      "affs": [
        1
      ],
      "name": "Yusuke Okada"
    },
    {
      "affs": [
        1
      ],
      "name": "Masaya Inoue"
    },
    {
      "affs": [
        0
      ],
      "name": "Shintaro Shimizu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hirotoki Tsuda"
    },
    {
      "affs": [
        0
      ],
      "name": "Kojiro Hata"
    },
    {
      "affs": [
        0
      ],
      "name": "Takae Okuno"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshihiro Amano"
    },
    {
      "affs": [
        0
      ],
      "name": "Mika Nakao"
    },
    {
      "affs": [
        0
      ],
      "name": "Kazuhisa Nakashima",
      "orcid": "0000-0001-8687-1437"
    },
    {
      "affs": [
        0
      ],
      "name": "Megumi Hamaguchi",
      "orcid": "0000-0002-1995-9217"
    },
    {
      "affs": [
        0
      ],
      "name": "Takeshi Isobe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8amv3vtr87eqe.bib",
  "cited_by": 0,
  "doi": "10.1002/rcr2.70804",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727363/?tool=EBI",
  "id": "8amv3vtr87eqe",
  "issns": [
    "2051-3380"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727363",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Series"
    ],
    [
      "openalex",
      "2725|COVID-19 Clinical Research Studies"
    ]
  ],
  "openalex": "W7225116057",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727363/pdf/?tool=EBI",
  "pmcid": "PMC13727363",
  "pmid": "42974628",
  "published": "2026-11-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/8amv3vtr87eqe.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727363",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727363"
    },
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974628",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974628"
    },
    {
      "first_seen": "2026-11-05T12:23:27Z",
      "native_id": "PMC13727363",
      "source": "pmc",
      "url": "https://doi.org/10.1002/rcr2.70804"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|COVID-19 Clinical Research Studies",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Persistent Coronavirus Disease 2019 (COVID‐19) in Patients With Malignant Lymphoma Treated With Anti‐CD20 Antibodies Who Responded to Ensitrelvir: A Report of Three Cases",
  "title_text": "Persistent Coronavirus Disease 2019 (COVID‐19) in Patients With Malignant Lymphoma Treated With Anti‐CD20 Antibodies Who Responded to Ensitrelvir: A Report of Three Cases",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:23:27Z",
  "url": "https://research.draconitic.com/paper/8amv3vtr87eqe",
  "venue": "Respirology case reports",
  "versions": []
}