{
  "abstract": "Irritable bowel syndrome (IBS) is a prevalent yet poorly understood functional gut disorder frequently associated with microbial dysbiosis, making microbiome-targeting interventions a promising management strategy. In this study, we evaluated the microbiome-modulating potential of three doses of triacetin (TA; ReBiome™; 100, 200 and 300 mg/day) and two finished formulations containing TA and/or tributyrin (TB): Active Biome™ (AB) and Bio Complete 3™ (BC3). Inulin served as a benchmark prebiotic. The validated ex vivo Systemic Intestinal Fermentation Research (SIFR®) technology pipeline was applied using fecal microbiota from eight adults with IBS. TA dose-dependently increased short-chain fatty acid (SCFA) levels from 100 mg/day, significantly increasing acetate and butyrate while maintaining low gas formation. In addition to acetate and butyrate, AB and BC3 also promoted propionate while BC3 induced a particularly pronounced butyrate increase. Overall, both formulations induced stronger SCFA but milder gas increases than inulin. TA, AB and BC3 enriched IBS-depleted, butyrate-associated OTUs related to Faecalibacterium and Anaerobutyricum species. AB and BC3 increased microbial diversity (community modulation score (CMS)) by promoting Bifidobacteriaceae, Lachnospiraceae and Bacteroidaceae. Overall, TA and TA/TB-containing formulations promoted butyrate production, potentially helping mitigate IBS symptom severity by inducing a favorable fermentation profile with limited gas formation.",
  "abstract_shown": true,
  "affiliations": [
    "Cryptobiotix SA, Technologiepark-Zwijnaarde 82, 9052 Ghent, Belgium",
    "Gundry MD®, 145 S. Fairfax Avenue, Suite 200, Los Angeles, CA 90036, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liam Jenkins Sánchez",
      "orcid": "0000-0002-2932-3191"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonas Poppe"
    },
    {
      "affs": [
        0
      ],
      "name": "Aurélien Baudot",
      "orcid": "0009-0009-4872-6875"
    },
    {
      "affs": [
        0
      ],
      "name": "Lam Dai Vu"
    },
    {
      "affs": [
        1
      ],
      "name": "Will Villella"
    },
    {
      "affs": [
        0
      ],
      "name": "Pieter Van den Abbeele",
      "orcid": "0000-0002-1399-6332"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8b09chehkap32.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198910",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665126/?tool=EBI",
  "id": "8b09chehkap32",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13665126",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7221178628",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13665126/pdf/?tool=EBI",
  "pmcid": "PMC13665126",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8b09chehkap32.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "PMC:PMC13665126",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13665126"
    },
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198910",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8910"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Gut microbiota and health",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Impact of Triacetin- and Tributyrin-Based Formulations on IBS Microbiome Composition and SCFA Profiles: A Preclinical Study",
  "title_text": "Impact of Triacetin- and Tributyrin-Based Formulations on IBS Microbiome Composition and SCFA Profiles: A Preclinical Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:55Z",
  "url": "https://research.draconitic.com/paper/8b09chehkap32",
  "venue": "International journal of molecular sciences",
  "versions": []
}