{
  "abstract": "Purpose of Review: Chest radiotherapy has improved cancer survival in various thoracic malignancies, including breast cancer, Hodgkin lymphoma, and lung cancer. However, inadvertent radiation exposure to the heart is associated with a broad spectrum of cardiovascular toxicities, collectively termed radiation-induced heart disease (RIHD). We aim to review the pathophysiology of RIHD and the current evidence for their incidence, risk factors, clinical management, and prevention strategies.\n\nRecent Findings: RIHD is mediated by oxidative stress, DNA damage, endothelial dysfunction, inflammation, and progressive fibrosis, leading to accelerated atherosclerosis, myocardial stiffening, valvular degeneration, pericardial disease, and arrhythmias. The risk, timing, and severity of cardiovascular complications are influenced by radiation dose and distribution, age at exposure, baseline cardiovascular risk, and concomitant cardiotoxic therapies. While younger patients may experience prolonged latency before clinical disease onset, older individuals and those with pre-existing cardiovascular disease often develop complications earlier, reflecting radiation-mediated acceleration of underlying pathology.\n\nSummary: This review summarizes the epidemiology, latency, clinical presentation, surveillance strategies, and management of the different forms of RIHD. It also discusses contemporary approaches to risk mitigation, including advances in radiation delivery techniques, aggressive cardiovascular risk factor modification, lifestyle interventions, and emerging pharmacologic strategies.\n\nGraphical Abstract:",
  "abstract_shown": true,
  "affiliations": [
    "Cardiology Division, Hartford Hospital, University of Connecticut, Hartford, CT 06102 USA",
    "Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, 1400 Pelham Parkway South, Bronx, NY 10461 USA",
    "Cardiology Division, Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, 111 E 210th St, Bronx, NY 10467 USA"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Raksheeth Agarwal",
      "orcid": "0000-0003-4045-2784"
    },
    {
      "affs": [
        1
      ],
      "name": "Antony Gonzalo Gonzales-Uribe",
      "orcid": "0000-0001-5068-9596"
    },
    {
      "affs": [
        2
      ],
      "name": "Lili Zhang",
      "orcid": "0000-0002-9341-5832"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8b2ydv8mdpzfy.bib",
  "cited_by": 0,
  "doi": "10.1007/s11886-026-02437-6",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714108/",
  "id": "8b2ydv8mdpzfy",
  "issns": [
    "1523-3782",
    "1534-3170"
  ],
  "landing_url": "https://doi.org/10.1007/s11886-026-02437-6",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7223789476",
  "pdf_url": null,
  "pmcid": "PMC13714108",
  "pmid": "42945009",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8b2ydv8mdpzfy.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:40Z",
      "native_id": "PMC13714108",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s11886-026-02437-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Chest Radiotherapy Associated Cardiotoxicity: An Update",
  "title_text": "Chest Radiotherapy Associated Cardiotoxicity: An Update",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:40Z",
  "url": "https://research.draconitic.com/paper/8b2ydv8mdpzfy",
  "venue": "Current Cardiology Reports",
  "versions": []
}