{
  "abstract": "A redox‐neutral hydroaminoalkylation strategy has been developed for the synthesis of 1,1‐disubstituted aminocyclopropanes from alkenes and alkynes. Through simple solvolysis activation, the reaction of an easily accessible, bench‐stable hemiaminal precursor allows excellent yields of the target products at ambient temperature. The approach presented herein has a substrate tolerance that is orthogonal to classical aminocyclopropane syntheses, and its deployment for the preparation of bioisosteres of pharmacologically active gem‐α‐dimethylamines resulted in improved biological properties.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Organic Chemistry University of Vienna Vienna Austria",
    "CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Vienna Austria",
    "Vienna Doctoral School in Chemistry University of Vienna Vienna Austria",
    "Center for Physiology and Pharmacology Institute of Pharmacology Medical University of Vienna Vienna Austria",
    "Hourani Center for Applied Scientific Research Al‐Ahliyya Amman University Amman Jordan",
    "Center for Addiction Research and Science Medical University of Vienna Vienna Austria"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gwyndaf A. Oliver",
      "orcid": "0000-0002-2936-6175"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Konstantin Günther",
      "orcid": "0000-0002-3874-1301"
    },
    {
      "affs": [
        3
      ],
      "name": "Chiara Sebastianelli‐Schoditsch",
      "orcid": "0009-0006-6973-9972"
    },
    {
      "affs": [
        0
      ],
      "name": "Sophie Woolford"
    },
    {
      "affs": [
        3
      ],
      "name": "Iina Ludwig"
    },
    {
      "affs": [
        3,
        4,
        5
      ],
      "name": "Harald H. Sitte",
      "orcid": "0000-0002-1339-7444"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Nuno Maulide",
      "orcid": "0000-0003-3643-0718"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8b7cnrc38y5q4.bib",
  "cited_by": 0,
  "doi": "10.1002/anie.8092854",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725555/",
  "id": "8b7cnrc38y5q4",
  "issns": [
    "1433-7851",
    "1521-3773"
  ],
  "landing_url": "https://doi.org/10.1002/anie.8092854",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Communication"
    ],
    [
      "openalex",
      "1605|Cyclopropane Reaction Mechanisms"
    ]
  ],
  "openalex": "W7208789818",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.8092854",
  "pmcid": "PMC13725555",
  "pmid": "42695198",
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8b7cnrc38y5q4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:54Z",
      "native_id": "PMC13725555",
      "source": "pmc",
      "url": "https://doi.org/10.1002/anie.8092854"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclopropane Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation",
  "title_text": "Synthesis of Aminocyclopropanes by Redox‐Neutral Aminoalkylation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:46Z",
  "url": "https://research.draconitic.com/paper/8b7cnrc38y5q4",
  "venue": "Angewandte Chemie (International Ed. in English)",
  "versions": []
}