{
  "abstract": "ObjectivesTo compare high-sensitivity C-reactive protein (hsCRP) profiles in Korean and US adults with low-density lipoprotein cholesterol (LDL-C) below 100 mg/dL and examine differences after adiposity adjustment.\n\nStudy designCross-sectional analysis of national health examination surveys.\n\nMethodsWe analysed the Korea National Health and Nutrition Examination Survey 2022-2024 (n=5,785) and US National Health and Nutrition Examination Survey August 2021-August 2023 (n=1,056). Eligible adults had Sampson-calculated LDL-C <100 mg/dL and hsCRP [≤]10 mg/L; elevated hsCRP was defined as 2-10 mg/L. We estimated survey-weighted prevalence differences and adjusted prevalence ratios (PRs).\n\nResultsLDL-C distributions closely overlapped (weighted medians, 79.7 vs 80.1 mg/dL), whereas median hsCRP was 0.50 vs 1.34 mg/L. Elevated-hsCRP prevalence was 12.2% in Korea and 35.7% in the United States (difference, 23.5 percentage points; 95% CI, 19.4-27.7); the age-sex-standardised difference was 23.4 percentage points. Among 6,235 common complete cases, the age-sex-adjusted US-versus-Korea PR was 2.86 (95% CI, 2.48-3.30), decreasing to 1.66 (1.40-1.98) after waist circumference adjustment and 1.92 (1.62-2.26) after body mass index adjustment.\n\nConclusionsSimilar LDL-C distributions coexisted with markedly different hsCRP profiles. Waist adjustment attenuated the between-country contrast more than BMI adjustment, supporting joint consideration of inflammatory, lipid and anthropometric measures in population surveillance.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "J. TENG"
    },
    {
      "name": "J. XIA"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8bcsydwz31cwc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.14.26365531",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.10.14.26365531v1.full",
  "id": "8bcsydwz31cwc",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.10.14.26365531v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "epidemiology"
    ],
    [
      "openalex",
      "2746|Lipoproteins and Cardiovascular Health"
    ]
  ],
  "openalex": "W7222309416",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.10.14.26365531v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8bcsydwz31cwc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:57Z",
      "native_id": "10.64898/2026.10.14.26365531",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.10.14.26365531v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:epidemiology",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "High-sensitivity C-reactive protein profiles differ between Korean and US adults with LDL cholesterol below 100 mg/dL",
  "title_text": "High-sensitivity C-reactive protein profiles differ between Korean and US adults with LDL cholesterol below 100 mg/dL",
  "type": "preprint",
  "updated_at": "2026-10-30T12:20:57Z",
  "url": "https://research.draconitic.com/paper/8bcsydwz31cwc",
  "venue": "medRxiv",
  "versions": []
}