{
  "abstract": "Cirrhosis-associated immune dysfunction (CAID) contributes to poor outcomes after liver transplantation (LT), but pre-transplant immune predictors remain insufficiently defined. We investigated whether pre-transplant whole blood transcriptomic profiling was associated with post-LT outcomes in this exploratory ancillary study of the prospective EDMONHG cohort. Transcriptomic analysis of 26 immune-related genes was performed on 97 LT recipients. PCA and volcano plots identified candidate biomarkers; associations with outcomes were assessed using ROC analyses and Kaplan-Meier estimates with cohort medians as thresholds. PC1 (43.5% of variance) decreased progressively from cACLD to ALF (p < 0.001) and was lower in post-LT infected patients (p = 0.044). Within the first month, 34 patients (35%) developed infections; 7 (7.2%) died within 1 year. Three genes met predefined exploratory criteria (q < 0.10, AUC > 0.65) for infections: GNLY and IL7R were downregulated and IL10 upregulated. Low GNLY or high IL10 expression was associated with reduced 30-day infection-free survival (p = 0.019 and p = 0.013). CIITA, IL10, CD177 and S100A9 showed associations with one-year survival, though results should be treated as exploratory given the limited number of events. Pre-transplant transcriptomics captures CAID severity and identifies candidate gene signatures associated with post-LT outcomes. These hypothesis-generating findings warrant validation in larger multicenter cohorts.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Marie-Charlotte Delignette"
    },
    {
      "name": "Estelle Peronnet"
    },
    {
      "name": "Arnaud Riff"
    },
    {
      "name": "Teresa Antonini"
    },
    {
      "name": "Maxime Bodinier"
    },
    {
      "name": "Elisabeth Cerrato"
    },
    {
      "name": "Solène Pantel"
    },
    {
      "name": "Elsa Coz"
    },
    {
      "name": "Xavier Muller"
    },
    {
      "name": "Guillaume Rossignol"
    },
    {
      "name": "Jean-Yves Mabrut"
    },
    {
      "name": "Jérôme Dumortier"
    },
    {
      "name": "Céline Guichon"
    },
    {
      "name": "Alice Blet"
    },
    {
      "name": "Frederic Aubrun"
    },
    {
      "name": "Guillaume Monneret"
    },
    {
      "name": "Fanny Lebossé"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8bsap5q0gjcjt.bib",
  "cited_by": 0,
  "doi": "10.3389/ti.2026.16292",
  "fulltext_url": null,
  "id": "8bsap5q0gjcjt",
  "issns": [
    "0934-0874",
    "1432-2277"
  ],
  "landing_url": "https://hal.science/hal-05799844v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.spee"
    ],
    [
      "openalex",
      "2746|Organ Transplantation Techniques and Outcomes"
    ]
  ],
  "openalex": "W7204576885",
  "pdf_url": "https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2026.16292/pdf",
  "pmcid": null,
  "pmid": "42729608",
  "published": "2026-08-28",
  "publisher": "Frontiers Media",
  "ris": "https://research.draconitic.com/paper/8bsap5q0gjcjt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "hal-05799844",
      "source": "hal",
      "url": "https://hal.science/hal-05799844v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:0.sdv",
      "subfield": "general"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.spee",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Pre-transplant whole blood transcriptomic profiling identifies mRNAs linked to cirrhosis-associated immune dysfunction as candidate predictors of clinical outcomes after liver transplantation: an exploratory study",
  "title_text": "Pre-transplant whole blood transcriptomic profiling identifies mRNAs linked to cirrhosis-associated immune dysfunction as candidate predictors of clinical outcomes after liver transplantation: an exploratory study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/8bsap5q0gjcjt",
  "venue": "Transplant International",
  "versions": []
}