{
  "abstract": "Muscle function can recover before damaged contractile structures are fully repaired, but the mechanisms enabling this recovery remain poorly understood. Using a temperature-sensitive Caenorhabditis elegans model of UNC-45 dysfunction, in which impaired myosin chaperoning triggers muscle proteotoxic stress and reversible paralysis, we show that coordinated movement recovers while sarcomere disorganisation persists. Quantitative proteomics identified ALLO-1, a selective-autophagy receptor previously characterised for paternal organelle clearance during embryogenesis, as induced during recovery from UNC-45dependent muscle stress. Functional and proteomic analyses revealed an ALLO-1–associated regulatory network comprising IKKE-1, SIP-1, DIM-1 and CAR-1 that modulates mitochondrial stress responses and muscle recovery. Loss of ALLO-1 or its associated factors altered mitochondrial homoeostasis and delayed functional recovery, whereas muscle-specific ALLO-1a restoration improved recovery, preserved mitochondrial network integrity, and modulated mitochondrial turnover despite reduced respiratory capacity. These findings identify ALLO-1 as a regulator of mitochondrial stress adaptation that enables functional recovery before completing structural repair.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Anwesha Sarkar",
      "orcid": "0000-0002-2150-9653"
    },
    {
      "name": "Lilla Biriczová",
      "orcid": "0000-0002-7054-0358"
    },
    {
      "name": "Natalia A. Szulc",
      "orcid": "0000-0002-2991-3634"
    },
    {
      "name": "Pankaj Thapa"
    },
    {
      "name": "Remigiusz Serwa",
      "orcid": "0000-0002-4684-3754"
    },
    {
      "name": "Wojciech Pokrzywa",
      "orcid": "0000-0002-5110-4462"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8bthmnb7ph2eb.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11093-z",
  "fulltext_url": "https://europepmc.org/articles/PMC13669348",
  "id": "8bthmnb7ph2eb",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11093-z",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Autophagy in Disease and Therapy"
    ]
  ],
  "openalex": "W7220740105",
  "pdf_url": "https://www.nature.com/articles/s42003-026-11093-z.pdf",
  "pmcid": "PMC13669348",
  "pmid": "42875476",
  "published": "2026-10-06",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/8bthmnb7ph2eb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:50Z",
      "native_id": "10.1038/s42003-026-11093-z",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11093-z"
    },
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42875476",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42875476"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Autophagy in Disease and Therapy",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "An ALLO-1–associated network links mitochondrial quality control to functional recovery in structurally compromised muscle",
  "title_text": "An ALLO-1–associated network links mitochondrial quality control to functional recovery in structurally compromised muscle",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/8bthmnb7ph2eb",
  "venue": "Communications Biology",
  "versions": []
}