{
  "abstract": "Background:: Interleukin (IL)-6 is a proinflammatory cytokine that has been shown to mediate inflammation in several chronic diseases, including diabetes mellitus and cardiovascular disease. It has emerged in the past decade as a potential biomarker for asthma in adults, but an IL-6-high phenotype in children has yet to be defined.\n\nObjective:: To determine whether an IL-6 high phenotype could be identified in children with asthma and its relation to other clinical and biologic characteristics previously identified as significant in individuals with asthma.\n\nMethods:: We conducted a single-center, prospective, observational study to quantify plasma IL-6 levels in children aged 6 to 17 years from an urban outpatient clinic. Both children with asthma and controls without asthma were recruited. Blood samples, lung function testing, and questionnaires were collected at a single study visit.\n\nResults:: An IL-6-high phenotype was identified in this diverse pediatric population that was not seen in healthy controls. High plasma IL-6 levels were associated with obesity, high C-reactive protein, and neutrophilia but not with age, asthma severity, plasma IL-6 receptor levels, or plasma fatty acid levels. High IL-6 levels were not distinct from type 2-associated inflammation; rather, the 2 revealed significant overlap.\n\nConclusion:: In our single-center study, an IL-6-high phenotype was identified in children with asthma that was associated with obesity and neutrophilia but was not independent of atopic disease. Further work is needed to determine whether IL-6 modulation can impact asthma morbidity in children.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, The University of Chicago, Chicago, Illinois",
    "Pritzker School of Medicine, The University of Chicago, Chicago, Illinois",
    "Department of Medicine, The University of Chicago, Chicago, Illinois"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "So Lim Kim"
    },
    {
      "affs": [
        0
      ],
      "name": "Jamel I. Mansur"
    },
    {
      "affs": [
        0
      ],
      "name": "Elizabeth Carr"
    },
    {
      "affs": [
        1
      ],
      "name": "Nydia Kung"
    },
    {
      "affs": [
        0
      ],
      "name": "Matthew Moy"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ruchi Singla"
    },
    {
      "affs": [
        0
      ],
      "name": "Steve W. Handoyo"
    },
    {
      "affs": [
        2
      ],
      "name": "Valerie G. Press"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Sharmilee M. Nyenhuis"
    },
    {
      "affs": [
        2
      ],
      "name": "Bharathi Laxman"
    },
    {
      "affs": [
        2
      ],
      "name": "Steven White"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Christina E. Ciaccio"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8c7h32x12a6vv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.anai.2026.09.729",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720908/",
  "id": "8c7h32x12a6vv",
  "issns": [
    "1081-1206",
    "1534-4436"
  ],
  "landing_url": "https://doi.org/10.1016/j.anai.2026.09.729",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2737|Asthma and respiratory diseases"
    ]
  ],
  "openalex": "W7213132873",
  "pdf_url": "https://www.annallergy.org/article/S1081-1206(26)01177-4/pdf",
  "pmcid": "PMC13720908",
  "pmid": "42735798",
  "published": "2026-09-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8c7h32x12a6vv.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:42Z",
      "native_id": "PMC13720908",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.anai.2026.09.729"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Asthma and respiratory diseases",
      "subfield": "physiology"
    }
  ],
  "title": "An interleukin (IL)-6 high phenotype in children with asthma is associated with obesity and neutrophilia",
  "title_text": "An interleukin (IL)-6 high phenotype in children with asthma is associated with obesity and neutrophilia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:42Z",
  "url": "https://research.draconitic.com/paper/8c7h32x12a6vv",
  "venue": "Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology",
  "versions": []
}