{
  "abstract": "Wearable electrochemical sensors offer promising opportunities for wound-related biochemical assessment by enabling the detection of wound-relevant biomarkers directly at the skin-wound interface. In this study, we present a textile-integrated sensor platform for dual-analyte response of hydrogen peroxide (H₂O₂) and enzymatically quantified lactate, which are key indicators of oxidative stress and metabolic activity, respectively. The redox sensor was fabricated using platinum-coated Shieldex working electrodes and Ag/AgCl reference electrodes, arranged in a coaxial winding yarn. Besides having the same type of reference electrode in the setup, the lactate sensor employed a gold-based working electrode functionalized with a chitosan-PPD-lactate oxidase (LOx) multilayer along with a platinum-based counter electrode. Electrochemical characterisation showed that the redox sensor exhibited consistent current-time response behaviour, approaching a quasi-stabilised response level within approximately 180 s, and demonstrating a measurable response trend across a broad experimentally explored H₂O₂ concentration range (from the micromolar to high millimolar range). The lactate sensor produced repeatable qualitative current increases of approximately 25% and 50% at 2 mM and 4 mM lactate, respectively, with response magnitude affected by pH and temperature. Biocompatibility testing confirmed no cytotoxic effects for gold- and platinum-based electrodes, and only moderate effects for Ag/AgCl under prolonged incubation, supporting the suitability of the primary sensing elements for wound-contact applications. Taken together, the results demonstrate proof-of-concept functionality under controlled laboratory conditions, while comprehensive analytical validation remains the subject of future work, which supports the potential of textile-based electrochemical sensors for integration into next-generation smart wound dressings. Future research will also focus on environmental compensation, enzyme stabilisation and further system optimisation for wound-relevant operation.",
  "abstract_shown": true,
  "affiliations": [
    "Institute of Textile Machinery and High Performance Material Technology, Technische Universität Dresden, Dresden, Germany.",
    "Institut für Fördertechnik und Kunststoffe, Technische Universität Chemnitz, Chemnitz, Germany.",
    "Textilforschungsinstitut Thueringen-Vogtland e.V.-TITV Greiz, Yvonne Zimmermann, Greiz, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adnan Maroof Khan",
      "orcid": "0000-0002-1749-1710"
    },
    {
      "affs": [
        1
      ],
      "name": "Johannes Wendler",
      "orcid": "0000-0001-6915-5383"
    },
    {
      "affs": [
        2
      ],
      "name": "Yvonne Zimmermann",
      "orcid": "0009-0009-1062-3432"
    },
    {
      "affs": [
        0
      ],
      "name": "Dilbar Aibibu",
      "orcid": "0000-0002-7440-9277"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael Wöltje",
      "orcid": "0000-0002-5405-0981"
    },
    {
      "affs": [
        0
      ],
      "name": "Chokri Cherif"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8dx67v9g2qq4a.bib",
  "cited_by": 0,
  "doi": "10.1111/iwj.71083",
  "fulltext_url": "https://europepmc.org/articles/PMC13720339",
  "id": "8dx67v9g2qq4a",
  "issns": [
    "1742-4801",
    "1742-481X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958837",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2208|Electrochemical sensors and biosensors"
    ]
  ],
  "openalex": "W7224881876",
  "pdf_url": "https://europepmc.org/articles/PMC13720339?pdf=render",
  "pmcid": "PMC13720339",
  "pmid": "42958837",
  "published": "2026-10-29",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/8dx67v9g2qq4a.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42958837",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958837"
    },
    {
      "first_seen": "2026-11-03T12:21:14Z",
      "native_id": "PMC13720339",
      "source": "pmc",
      "url": "https://doi.org/10.1111/iwj.71083"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Textile-Integrated Electrochemical Sensing Approaches for Monitoring Wound-Relevant Biochemical Markers.",
  "title_text": "Textile-Integrated Electrochemical Sensing Approaches for Monitoring Wound-Relevant Biochemical Markers.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:14Z",
  "url": "https://research.draconitic.com/paper/8dx67v9g2qq4a",
  "venue": "International wound journal",
  "versions": []
}