{
  "abstract": "Introduction: Triple-negative breast cancer remains a formidable clinical challenge owing to its immunosuppressive microenvironment and inherently low immunogenicity.\n\nMethods: To address this, we developed a multifunctional Pickering emulsion (Fe-PDA-PE-R837) stabilized by iron-doped polydopamine (Fe-PDA) nanoparticles, which function dually as photothermal agents and localized iron donors, while the soybean oil core encapsulates the immunoadjuvant R837. The Fe-PDA nanoparticles exhibited uniform spherical morphology, excellent colloidal stability, and a broad absorption band extending to the NIR region. Upon 808 nm laser irradiation, the Fe-PDA shell generates local hyperthermia with a photothermal conversion efficiency of 38.5%, disrupts intracellular iron homeostasis to provoke ferroptotic cell death, as evidenced by GSH depletion and MDA accumulation, while the stimuli-responsive release of R837 coupled with immunogenic cell death (ICD) elicits potent local and systemic pro-inflammatory responses.\n\nResults: In vitro assays demonstrated that the combination treatment achieved ∼80% cell killing, markedly inhibited cell migration, and significantly upregulated TNF-α and IL-12 secretion. In vivo evaluation using the 4T1 murine breast cancer model confirmed that this nanoplatform significantly suppressed primary tumor growth and pulmonary metastasis, with no appreciable systemic toxicity.\n\nDiscussion: Collectively, this interfacial engineering strategy underscores the promising translational potential of Pickering emulsion-based nanoplatforms for aggressive solid tumor therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Breast Surgery, Changzhou Cancer Hospital (The Fourth People’s Hospital of Changzhou)",
    "School of Materials Science and Engineering, Changzhou University"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ling-Yu Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Peng Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min-Jing Yu"
    },
    {
      "affs": [
        1
      ],
      "name": "Hao-Ran Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Chen Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiyan Gao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8e2jwweqhhh3z.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1956784",
  "fulltext_url": "https://europepmc.org/articles/PMC13685026",
  "id": "8e2jwweqhhh3z",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1956784/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2204|Nanoplatforms for cancer theranostics"
    ]
  ],
  "openalex": "W7220846594",
  "pdf_url": "https://europepmc.org/articles/PMC13685026?pdf=render",
  "pmcid": "PMC13685026",
  "pmid": "42909345",
  "published": "2026-10-07",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/8e2jwweqhhh3z.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:06Z",
      "native_id": "10.3389/fphar.2026.1956784",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1956784/full"
    },
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42909345",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42909345"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1663-9812",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Fe-doped polydopamine pickering emulsion as a nanoplatform for synergistic photothermal-ferroptosis immunotherapy in breast cancer",
  "title_text": "Fe-doped polydopamine pickering emulsion as a nanoplatform for synergistic photothermal-ferroptosis immunotherapy in breast cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/8e2jwweqhhh3z",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}