{
  "abstract": "Immune checkpoint inhibitor (ICI) therapy commonly leads to adverse events such as ICI-mediated diarrhea and colitis (IMDC). Fecal microbiota transplantation (FMT) remains an option for patients with refractory colitis. We report a multi-omics profiling of patients receiving first-line FMT for IMDC. In our preliminary analysis, 10 (76.9%) patients achieve clinical response, with a median time to clinical improvement of 1.5 (1–10.5) days. Among responder patients with baseline and follow-up samples, 6 (75%) show an increase in alpha-diversity post-FMT. Pre-FMT samples show an increase in the abundance scores of plasma cells, neutrophils, macrophages (M1 and M2), memory activated and resting memory CD4+ T cells, CD8+ T cells, T follicular helper (Tfh) cells, and regulatory T cells (Tregs), all of which decrease post-FMT. In a small cohort of patients, we identify potential mechanisms for FMT response and demonstrate that first-line FMT in patients with IMDC (NCT04038619) can be effective.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastroenterology, Hepatology & Nutrition, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Division of Gastroenterology and Hepatology, Department of Medicine, Houston Methodist Hospital, Houston, TX, USA",
    "Center for Infectious Diseases, Houston Methodist Research Institute, Houston, TX, USA",
    "Department of Medicine, Weill Cornell Medical College, New York, NY, USA",
    "Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Metabolomics Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Proteomics Core Facility, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Division of Infectious Disease, Department of Medicine, Houston Methodist Hospital, Houston, TX, USA",
    "The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Internal Medicine, School of Public Health, Houston, TX, USA",
    "Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA",
    "Departments of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA",
    "Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA",
    "Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, CA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 32,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yinghong Wang"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Christopher Fan"
    },
    {
      "affs": [
        0
      ],
      "name": "Krishnavathana Varatharajalu"
    },
    {
      "affs": [
        0
      ],
      "name": "Malek Shatila"
    },
    {
      "affs": [
        0
      ],
      "name": "Carolina Colli Cruz"
    },
    {
      "affs": [
        5
      ],
      "name": "Baohua Sun"
    },
    {
      "affs": [
        6
      ],
      "name": "Nejla Ozirmak Lermi"
    },
    {
      "affs": [
        1
      ],
      "name": "Tomo Hayase"
    },
    {
      "affs": [
        0
      ],
      "name": "Anusha Thomas"
    },
    {
      "affs": [
        5
      ],
      "name": "Klaudia Anna Szymonowicz"
    },
    {
      "affs": [
        5
      ],
      "name": "Beatriz Sanchez Espiridion"
    },
    {
      "affs": [
        5
      ],
      "name": "Dzifa Yawa Duose"
    },
    {
      "affs": [
        1
      ],
      "name": "Eiko Hayase"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Lin Tan"
    },
    {
      "affs": [
        6,
        8
      ],
      "name": "Yiwei Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chia-Chi Chang"
    },
    {
      "affs": [
        9,
        3,
        4
      ],
      "name": "Cesar A. Arias"
    },
    {
      "affs": [
        0
      ],
      "name": "Kristin Junek"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Herbert L. DuPont"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Zhi-Dong Jiang"
    },
    {
      "affs": [
        12
      ],
      "name": "Sang T. Kim"
    },
    {
      "affs": [
        13
      ],
      "name": "Roza Nurieva"
    },
    {
      "affs": [
        14
      ],
      "name": "Matthew T. Campbell"
    },
    {
      "affs": [
        14
      ],
      "name": "Nizar M. Tannir"
    },
    {
      "affs": [
        14
      ],
      "name": "Jianjun Gao"
    },
    {
      "affs": [
        13
      ],
      "name": "Stephanie S. Watowich"
    },
    {
      "affs": [
        15
      ],
      "name": "Xin Shelley Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Ken Chen"
    },
    {
      "affs": [
        6,
        7,
        8
      ],
      "name": "Philip L. Lorenzi"
    },
    {
      "affs": [
        5
      ],
      "name": "Cara Haymaker"
    },
    {
      "affs": [
        5
      ],
      "name": "Edwin Roger Parra"
    },
    {
      "affs": [
        16
      ],
      "name": "Robert R. Jenq"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8e5vwvj2y59ef.bib",
  "cited_by": 1,
  "doi": "10.1016/j.xcrm.2026.103044",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710150/",
  "id": "8e5vwvj2y59ef",
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  "language": "en",
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  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
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  "pmcid": "PMC13710150",
  "pmid": "42735684",
  "published": "2026-09-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/8e5vwvj2y59ef.ris",
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      "field": "medicine",
      "origin": "openalex:2730|Cancer Immunotherapy and Biomarkers",
      "subfield": "oncology"
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  ],
  "title": "First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis",
  "title_text": "First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:10Z",
  "url": "https://research.draconitic.com/paper/8e5vwvj2y59ef",
  "venue": "Cell Reports Medicine",
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}