{
  "abstract": "The female reproductive tract is essential for fertility, pregnancy, and overall health, yet many of its cellular components remain poorly defined. Recent advances in single-cell and spatial transcriptomics have begun to reveal this complexity, but inconsistent naming of cell types and states has limited the ability to compare findings across studies. To address this challenge, an international group of reproductive biologists and ontology experts collaborated to harmonize annotations within Cell Ontology, focusing on the ovary, fallopian tube, and uterus. Standardized terms are proposed for major epithelial, stromal, and germ cell populations, supported by marker gene sets and anatomical linkages. This framework provides a shared reference that can be used to harmonize existing datasets and guide annotation of future studies, enabling consistent classification of oocytes, granulosa, theca, luteal, epithelial, stromal, and immune cells across tissues. By establishing a unified taxonomy, this work lays the foundation for integrating datasets, supporting cross-tissue comparisons, and advancing the understanding of reproductive biology, health, and disease.",
  "abstract_shown": true,
  "affiliations": [
    "Mechanobiology Institute, National University of Singapore, Singapore, Singapore.",
    "Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA.",
    "Department of Pediatrics, Division of Endocrinology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.",
    "Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.",
    "EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.",
    "Buck Institute for Research on Aging, Novato, CA, USA.",
    "Stowers Institute for Medical Research, Kansas City, MO, USA.",
    "Chan Zuckerberg Initiative Biohub, Redwood City, CA, USA.",
    "Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.",
    "Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.",
    "Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.",
    "Miller School of Medicine, Medical Campus, University of Miami, Miami, FL, USA.",
    "Sylvester Comprehensive Cancer Center, Miller School of Medicine, Medical Campus, University of Miami, Miami, FL, USA.",
    "Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.",
    "Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.",
    "Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA.",
    "Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.",
    "Nutrition College, Federal University of Pelotas, Pelotas, Brazil.",
    "Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.",
    "Center for Healthy Aging in Women, Buck Institute for Research on Aging, Novato, CA, USA.",
    "Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.",
    "Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Science, University of California, San Francisco, San Francisco, CA, USA.",
    "Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA, USA.",
    "Vitra Labs Inc., San Francisco, CA, USA.",
    "Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.",
    "Department of Medicine, Cardiovascular Research Center, Yale School of Medicine, New Haven, CT, USA.",
    "Department of Obstetrics, Gynecology and Women’s Health, School of Medicine, University of Missouri-Columbia, Columbia, MO, USA.",
    "New York Genome Center, New York, NY, USA.",
    "Cancer Biology Department, USC Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, CA, USA.",
    "Pharmacology and Pharmaceutical Sciences Department, USC Mann School of Pharmacy and Pharmacology, Los Angeles, CA, USA.",
    "USC Stem Cell Initiative, Los Angeles, CA, USA.",
    "Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.",
    "Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.",
    "Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.",
    "Division of Animal Sciences, College of Agriculture, Food and Natural Resources, University of Missouri-Columbia, Columbia, MO, USA.",
    "Department of Molecular Genetics and Genome Sciences, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, OK, USA.",
    "Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.",
    "Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.",
    "Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.",
    "Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 51,
  "authors": [
    {
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        0
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      "name": "Huan Ting Ong",
      "orcid": "0000-0003-1214-9198"
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        2
      ],
      "name": "Diane C. Saunders",
      "orcid": "0000-0002-8849-6746"
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      "name": "Caroline Eastwood",
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      "name": "Aleix Puig-Barbe",
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      "name": "Alison Kochersberger",
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      "name": "Chen Jin",
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      "name": "Daniela Betancur",
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      "name": "Xifan Wang",
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      "name": "Xingyu Shen",
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      "name": "Bikem Soygur",
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      "name": "Brian Aevermann",
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      "name": "Eliza A. Gaylord",
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      "name": "Mariko H. Foecke",
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      "name": "Norbert K. Tavares",
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      "name": "Ryan M. Samuel",
      "orcid": "0000-0002-9473-1378"
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        25
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      "name": "Sophia Szady",
      "orcid": "0009-0004-5988-1831"
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        26
      ],
      "name": "Srinivasan Mahalingam"
    },
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        16
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      "name": "Subhasri Biswas",
      "orcid": "0000-0002-7204-5158"
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        27
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      "name": "Will Liao",
      "orcid": "0000-0001-7574-4694"
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        18,
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      ],
      "name": "Bérénice A. Benayoun",
      "orcid": "0000-0002-7401-4777"
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      "name": "Hattie Chung",
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      "name": "Wipawee Winuthayanon",
      "orcid": "0000-0002-5196-8471"
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      "name": "Jun Z. Li",
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        39
      ],
      "name": "Matteo A. Molè",
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    {
      "name": "Michael Angelo",
      "orcid": "0000-0003-1531-5067"
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      "name": "Patricia Jeudin",
      "orcid": "0000-0001-7280-7231"
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    {
      "name": "Ronny Drapkin",
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      "name": "Ariella Shikanov",
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      "name": "Diana J. Laird",
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      "name": "Francesca Duncan",
      "orcid": "0000-0002-3756-9394"
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      "name": "Hui Shen",
      "orcid": "0000-0001-9767-4084"
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        18,
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      "name": "Jennifer L. Garrison",
      "orcid": "0000-0002-5621-2139"
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      "name": "Mariana Boroni",
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      "name": "Michael B. Stout",
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      "name": "Roser Vento-Tormo",
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        12
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      "name": "Sophia H. L. George",
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      "name": "Yousin Suh",
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      "name": "Jennifer L. Young",
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      "name": "Monica M. Laronda",
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  ],
  "bibtex": "https://research.draconitic.com/paper/8eakegyhcnmd7.bib",
  "cited_by": 0,
  "doi": "10.1126/sciadv.aef2358",
  "fulltext_url": null,
  "id": "8eakegyhcnmd7",
  "issns": [
    "2375-2548"
  ],
  "landing_url": "https://www.science.org/doi/10.1126/sciadv.aef2358",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Biomedical Text Mining and Ontologies"
    ]
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  "openalex": "W7221123487",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-09",
  "publisher": "American Association for the Advancement of Science (AAAS)",
  "ris": "https://research.draconitic.com/paper/8eakegyhcnmd7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:41Z",
      "native_id": "10.1126/sciadv.aef2358",
      "source": "crossref",
      "url": "https://www.science.org/doi/10.1126/sciadv.aef2358"
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  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Biomedical Text Mining and Ontologies",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract",
  "title_text": "Standardizing Cell Ontology terms for cross-study integration in the female reproductive tract",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:41Z",
  "url": "https://research.draconitic.com/paper/8eakegyhcnmd7",
  "venue": "Science Advances",
  "versions": []
}