{
  "abstract": "Drug-induced hypercholesterolemia is well known to cause side effects, such as secondary hypercholesterolemia. Many of these drugs are essential for long-term use and are difficult to replace; therefore, they are continued even when associated with hypercholesterolemia. Mesalazine is the first-line drug used for treating ulcerative colitis. We herein report a case of severe hypercholesterolemia following mesalazine administration in a patient with ulcerative colitis. In this case, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor was effective in dramatically improving severe hypercholesterolemia. Clinicians should therefore be aware of the possibility of severe hypercholesterolemia caused by mesalazine for educational purposes.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "Takatoshi Anno"
    },
    {
      "name": "Kazutoshi Murakami"
    },
    {
      "name": "Shuhei Nakanishi"
    },
    {
      "name": "Jun Wada"
    },
    {
      "name": "Kohei Kaku"
    },
    {
      "name": "Hideaki Kaneto"
    },
    {
      "name": "Shinji Kamei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8ec13hzeet2xq.bib",
  "cited_by": 1,
  "doi": "10.2169/internalmedicine.6599-25",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6599-25/_article",
  "id": "8ec13hzeet2xq",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6599-25/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7117237193",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6599-25/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8ec13hzeet2xq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.6599-25",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6599-25/_article"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Severe Hypercholesterolemia Caused by Mesalazine Which Is a Key Drug of Ulcerative Colitis",
  "title_text": "Severe Hypercholesterolemia Caused by Mesalazine Which Is a Key Drug of Ulcerative Colitis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/8ec13hzeet2xq",
  "venue": "Internal Medicine",
  "versions": []
}