{
  "abstract": "Negative frequency-dependent selection (FDS) can increase both genetic diversity and population-level mean fitness. While the dual consequence of negative FDS has been theoretically recognized, its genomic basis remains unknown. To explore a genetic link between negative FDS and overyielding, I conducted a genome-wide association study (GWAS) of neighbour genotypic effects on the growth of 98 Arabidopsis thaliana genotypes. By incorporating neighbour genotypic similarity, this GWAS analysis detected the most significant single-nucleotide polymorphism (SNP) on the fifth chromosome of A. thaliana, which was 6 kbp from a known locus responsible for indirect genetic effects. I found negative FDS on the most significant SNP, where individual plants increased their biomass in the presence of neighbours with a dissimilar allele. I also observed overyielding in which a biallelic mixture of the most significant SNP showed a 3% increase in biomass compared with monoallelic conditions. Furthermore, I focused on the genomic region near the most significant SNP and found a signature of balancing selection near a negative regulator of ethylene responses, SIRTUIN 2. The present analysis uncovered a quantitative trait locus linking balanced polymorphisms and overyielding in A. thaliana, providing a proof of principle to understand the maintenance of polymorphism and its positive impact on population productivity. This article is part of the theme issue 'Exploring negative frequency-dependent selection across levels: from genetics to ecology and back again'.",
  "abstract_shown": true,
  "affiliations": [
    "Hokkaido University 1 , , ,",
    "University of Zurich 2 , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yasuhiro Sato",
      "orcid": "0000-0002-6466-723X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8ejj99a0egdr6.bib",
  "cited_by": 9,
  "doi": "10.1098/rstb.2025.0179",
  "fulltext_url": null,
  "id": "8ejj99a0egdr6",
  "issns": [
    "0962-8436",
    "1471-2970"
  ],
  "landing_url": "https://doi.org/10.1098/rstb.2025.0179",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Evolution and Genetic Dynamics"
    ]
  ],
  "openalex": "W7164388749",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42272391",
  "published": "2026-06-11",
  "publisher": "Royal Society",
  "ris": "https://research.draconitic.com/paper/8ejj99a0egdr6.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:07Z",
      "native_id": "W7164388749",
      "source": "openalex",
      "url": "https://doi.org/10.1098/rstb.2025.0179"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Evolution and Genetic Dynamics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Negative frequency-dependent selection underlies overyielding through neighbour genotypic effects in Arabidopsis thaliana",
  "title_text": "Negative frequency-dependent selection underlies overyielding through neighbour genotypic effects in Arabidopsis thaliana",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:43Z",
  "url": "https://research.draconitic.com/paper/8ejj99a0egdr6",
  "venue": "Philosophical Transactions of the Royal Society B Biological Sciences",
  "versions": []
}