{
  "abstract": "Uropathogenic E. coli (UPEC) is the predominant uropathogen in community-acquired urinary tract infections (CA-UTIs) globally. However, data from India on relationship between antimicrobial resistance, virulence factors, and clonal markers in UPEC remain scarce. We studied 80 ESBL-positive UPEC isolates causing CA-UTI across four Indian regions. Antimicrobial susceptibility done using VITEK-2. PCR assays detected ESBL genes ( bla CTX-M-15 , bla TEM ), carbapenemase genes ( bla NDM , bla OXA-48-like ), virulence genes ( fimH, pap, sfa, hlyA, aer ) and serogroup O25b. Phenotypic virulence assays assessed hemolysin, haemagglutination, biofilm and gelatinase production. All isolates susceptible to fosfomycin, with high susceptibility to nitrofurantoin (87.5%) and ertapenem (85%). Predominant resistance gene was bla CTX-M-15 (97.5%), followed by bla TEM (55%), bla NDM (16.3%) and bla OXA-48-like (5%). Biofilm formation (41.3%) most prevalent virulence trait, followed by haemagglutination (35%). Frequently detected virulence genes were pap (61.3%), fimH (55%), and aer (48.8%). The O25b serogroup found in 41.3% of isolates had lower ertapenem resistance than non-O25b strains. This study shows ESBL-producing UPEC isolates from community settings in India frequently harbour multiple beta-lactamase resistance genes and virulence factors, underscoring their adaptability and clinical threat in CA-UTIs. These findings emphasize the critical need for continued molecular surveillance, strengthened infection control, and robust antibiotic stewardship programs to mitigate the spread of multidrug-resistant, virulent UPEC strains.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "name": "Deepak Kocher"
    },
    {
      "name": "Swati Pundir"
    },
    {
      "name": "Sarita Mohapatra"
    },
    {
      "name": "Mani Kalaivani"
    },
    {
      "name": "Hitender Gautam"
    },
    {
      "name": "Seema Sood"
    },
    {
      "name": "Benu Dhawan"
    },
    {
      "name": "Brusabhanu Nayak"
    },
    {
      "name": "Arvind Kumar"
    },
    {
      "name": "Rajesh Kumari"
    },
    {
      "name": "Sandeep Mahajan"
    },
    {
      "name": "Pankaj Hari"
    },
    {
      "name": "Arti Kapil"
    },
    {
      "name": "Bimal Kumar Das"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8em4v0jqabm2h.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-70037-z",
  "fulltext_url": null,
  "id": "8em4v0jqabm2h",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-70037-z",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7215105810",
  "pdf_url": "https://www.nature.com/articles/s41598-026-70037-z_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/8em4v0jqabm2h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:19Z",
      "native_id": "10.1038/s41598-026-70037-z",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-70037-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:1313|Antibiotic Resistance in Bacteria",
      "subfield": "general"
    }
  ],
  "title": "Characteristics of ESBL-positive Escherichia coli causing community-acquired UTIs in India",
  "title_text": "Characteristics of ESBL-positive Escherichia coli causing community-acquired UTIs in India",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:19Z",
  "url": "https://research.draconitic.com/paper/8em4v0jqabm2h",
  "venue": "Scientific Reports",
  "versions": []
}