{
  "abstract": "Purpose\n\nClinical features of COPD and asthma overlap, complicating differential diagnosis. This study investigated the prevalence of comorbid asthma in COPD patients and its association with patient-related outcomes.Materials and methods\n\nPatients with a doctor's diagnosis of COPD were randomly selected in two cohorts 2005 (n = 1060) and 2014 (n = 1671), from primary and secondary care in Sweden. Data were collected from medical records and patient questionnaires at baseline and at follow-up (2012 and 2022, respectively). Questionnaires included data on exacerbations. Symptoms were assessed using the clinical COPD questionnaire (CCQ). Comorbid asthma was identified through medical records. Ten-year mortality data were obtained from national registers. Logistic and linear regression assessed associations with patient-reported outcomes; Cox regression was applied for mortality analyses.Results\n\nComorbid asthma was found in 22% of the 2005 cohort and 9% of the 2014 cohort (p < .001). In both cohorts, it was associated with an increased risk of exacerbations: OR (95% CI) 1.58 (1.07-2.32), p = .02, and 2.20 (1.38-3.52), p < .001, respectively. No associations were found between comorbid asthma and worsening of health status (CCQ). Mortality risk did not differ in the 2005 cohort, HR (95% CI) 0.92 (0.71-1.18), but was lower in the 2014 cohort, HR (95% CI) 0.67 (0.49-0.93), p = .02.Conclusion\n\nComorbid asthma in COPD has changed from 22 to 9%, potentially due to improved diagnostics. Comorbid asthma remains clinically relevant due to its association with an increased exacerbation risk.",
  "abstract_shown": true,
  "affiliations": [
    "School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.",
    "Department of Public Health and Caring Sciences, General Practice, Uppsala University, Uppsala, Sweden.",
    "Centre for Clinical Research and Education, Karlstad, Sweden.",
    "Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institute, Stockholm, Sweden.",
    "Academic Primary Care Centre, Stockholm, Sweden.",
    "Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.",
    "Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.",
    "Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.",
    "Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.",
    "Clinical Epidemiology Division, Department of Medicine, Karolinska Institute, Stockholm, Sweden.",
    "Department of Epidemiology and Public Health, University College, London, UK."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Åsa Athlin"
    },
    {
      "affs": [
        1
      ],
      "name": "Karin Lisspers"
    },
    {
      "affs": [
        2
      ],
      "name": "Mikael Hasselgren"
    },
    {
      "affs": [
        1
      ],
      "name": "Björn Ställberg"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Hanna Sandelowsky",
      "orcid": "0000-0002-1721-6540"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Maaike Giezeman",
      "orcid": "0000-0001-6261-6925"
    },
    {
      "affs": [
        5
      ],
      "name": "Christer Janson"
    },
    {
      "affs": [
        6
      ],
      "name": "Marta A Kisiel"
    },
    {
      "affs": [
        7
      ],
      "name": "Gabriella Eliason"
    },
    {
      "affs": [
        3
      ],
      "name": "Anna Nager"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Scott Montgomery"
    },
    {
      "affs": [
        7
      ],
      "name": "Josefin Sundh"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8f3mmkwjcvgw2.bib",
  "cited_by": 0,
  "doi": "10.1080/02813432.2026.2747915",
  "fulltext_url": "https://europepmc.org/articles/PMC13686181",
  "id": "8f3mmkwjcvgw2",
  "issns": [
    "0281-3432",
    "1502-7724"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894311",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7222948198",
  "pdf_url": "https://europepmc.org/articles/PMC13686181?pdf=render",
  "pmcid": "PMC13686181",
  "pmid": "42894311",
  "published": "2026-10-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8f3mmkwjcvgw2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42894311",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894311"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Comorbid asthma - occurrence and associations with patient-related outcomes in COPD: a cohort study.",
  "title_text": "Comorbid asthma - occurrence and associations with patient-related outcomes in COPD: a cohort study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/8f3mmkwjcvgw2",
  "venue": "Scandinavian journal of primary health care",
  "versions": []
}