{
  "abstract": "Background: This case report describes a novel subtype of testicular sex cord-stromal tumor, termed the “inflammatory and nested testicular sex cord tumor”, which is characterized by a specific EWSR1::ATF1 gene fusion. We present the clinicopathological features of this case to enhance the understanding of this extremely rare tumor.\n\nCase presentation: A 45-year-old male patient presented with a right testicular mass that had been present for six years without an identifiable cause. MRI conducted revealed a round nodule in the right testicular area, measuring approximately 38 × 28 mm, with relatively well-defined margins. The tumor exhibited a nodular growth, consisting of epithelial-like cells with abundant clear cytoplasm arranged in solid nests or sheets. Fibrous connective tissue surrounded the epithelial-like tumor nests, and focal inflammatory cell infiltration was observed within the stroma and tumor periphery. Immunohistochemistry showed membranous positivity for α-inhibin in the epithelial-like component. Molecular testing revealed an EWSR1::ATF1 gene fusion, leading to a final diagnosis of inflammatory and nested testicular sex cord tumor.\n\nConclusions: We report a novel subtype of testicular sex cord-stromal tumor, distinct from conventional forms, characterized by nest-like growth of clear epithelial-like tumor cells, focal inflammatory cell infiltration, and the presence of the EWSR1::ATF1 gene fusion. This case provides further evidence that supports the fusion pattern and clinicopathological basis for the newly proposed subtype of testicular sex cord-stromal tumor, inflammatory and nested testicular sex cord tumor.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, the First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832000 China",
    "Department of Pathology, Hongxing Hospital of the 13th Division of Xinjiang Production and Construction Corps, Xinxing, Xinjiang 839000 China",
    "Department of Pathology, School of Medicine, Shihezi University, Shihezi, Xinjiang 832000 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Li Wei"
    },
    {
      "affs": [
        1
      ],
      "name": "Shasha Lv"
    },
    {
      "affs": [
        1
      ],
      "name": "Qin Guo"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Wei Jia"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8fb17kbx18znw.bib",
  "cited_by": 0,
  "doi": "10.1186/s13000-026-01835-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737823/",
  "id": "8fb17kbx18znw",
  "issns": [
    "1746-1596"
  ],
  "landing_url": "https://doi.org/10.1186/s13000-026-01835-2",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Brief Report"
    ],
    [
      "openalex",
      "2746|Testicular diseases and treatments"
    ]
  ],
  "openalex": "W7202084410",
  "pdf_url": null,
  "pmcid": "PMC13737823",
  "pmid": "42983749",
  "published": "2026-08-10",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/8fb17kbx18znw.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:56Z",
      "native_id": "PMC13737823",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13000-026-01835-2"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Testicular diseases and treatments",
      "subfield": "surgery"
    }
  ],
  "title": "A case report of a novel inflammatory and incarcerated testicular stromal tumor associated with the EWSR1::ATF1 gene fusion",
  "title_text": "A case report of a novel inflammatory and incarcerated testicular stromal tumor associated with the EWSR1::ATF1 gene fusion",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:56Z",
  "url": "https://research.draconitic.com/paper/8fb17kbx18znw",
  "venue": "Diagnostic Pathology",
  "versions": []
}