{
  "abstract": "Free-living amoebae like Dictyostelium discoideum and environmental bacteria like Pseudomonas aeruginosa are engaged in complex predator-prey interactions. Amoeba can notably ingest and kill bacteria. In this study, we report that three different strains of the opportunistic pathogen Pseudomonas aeruginosa are protected from amoebal phagocytosis. Analysis of P. aeruginosa mutants revealed that OSA-type lipopolysaccharides (LPS) allow these P. aeruginosa strains to escape phagocytosis by amoebae. Amoebae can also kill extracellularly un-ingested P. aeruginosa bacteria. Our results indicate that induction of the Las quorum sensing (QS) makes P. aeruginosa resistant to reactive oxygen species, to bacteriolytic factors secreted by D. discoideum, and ultimately to extracellular destruction by amoebae. Together, these observations suggest that LPS and QS probably play a key role in P. aeruginosa escape strategies against phagocytic amoebae in the environment and shed new light on the transition of infectious P. aeruginosa from the environment to the human body.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "Imen Ayadi"
    },
    {
      "name": "Erwann Pain"
    },
    {
      "name": "Joseph Oddy"
    },
    {
      "name": "Otmane Lamrabet"
    },
    {
      "name": "Hitakshi Vijay"
    },
    {
      "name": "Thilo Koehler"
    },
    {
      "name": "Tania Distler"
    },
    {
      "name": "Alexandre Persat"
    },
    {
      "name": "Raphael Munoz-Ruiz"
    },
    {
      "name": "Pierre Cosson",
      "orcid": "0000-0002-4881-0358"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8ft9rhtm2nmwn.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117912",
  "fulltext_url": "https://europepmc.org/articles/PMC13695109",
  "id": "8ft9rhtm2nmwn",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03295-5",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "http://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cell biology"
    ],
    [
      "heading",
      "Microbial physiology"
    ],
    [
      "heading",
      "Proteomics"
    ],
    [
      "openalex",
      "1312|Bacterial biofilms and quorum sensing"
    ]
  ],
  "openalex": "W7222981637",
  "pdf_url": "https://europepmc.org/articles/PMC13695109?pdf=render",
  "pmcid": "PMC13695109",
  "pmid": "42926945",
  "published": "2026-10-19",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/8ft9rhtm2nmwn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:16Z",
      "native_id": "10.1016/j.isci.2026.117912",
      "source": "feed-cell",
      "url": "https://www.cell.com/iscience/fulltext/S2589-0042(26)03295-5"
    },
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1016/j.isci.2026.117912",
      "source": "crossref",
      "url": "https://linkinghub.elsevier.com/retrieve/pii/S2589004226032955"
    },
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42926945",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42926945"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "heading:Proteomics",
      "subfield": "proteomics-metabolomics"
    },
    {
      "field": "biology",
      "origin": "heading:Cell biology",
      "subfield": "cell-biology"
    }
  ],
  "title": "LPS and quorum sensing protect Pseudomonas aeruginosa bacteria from phagocytosis and destruction by Dictyostelium discoideum amoebae",
  "title_text": "LPS and quorum sensing protect Pseudomonas aeruginosa bacteria from phagocytosis and destruction by Dictyostelium discoideum amoebae",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/8ft9rhtm2nmwn",
  "venue": "iScience",
  "versions": []
}