{
  "abstract": "Porcine reproductive and respiratory syndrome virus (PRRSV) represents a constant challenge for the swine industry, both in Mexico and internationally, due to its high genetic variability and immunosuppressive capacity. This study evaluated the comparative efficacy of four modified-live vaccines in 3 to 4-wk-old seronegative piglets challenged intramuscularly with the heterologous PRRSV strain DAP150520 at 35 d post-vaccination (dpv; 0 d post-challenge, dpc). Fifty piglets were randomly allocated into five groups (n = 10/group): G1, ATCC-VR-2332; G2, SJO151012 ≥ 104 (Porcimune); G3, P129; G4, attenuated Nebraska ≥ 4.0; and G5, unvaccinated controls. Outcomes included ELISA seroconversion, qRT-PCR cycle threshold (Ct) values (PRRSV RNA detection), daily clinical scoring, BW, and gross lung lesions assessed using the modified Madec scale at 7 dpc. Group 2 (Porcimune) showed complete seroconversion from 21 dpv, controlled post-challenge viremia (cycle threshold [Ct] = 21.84 at 7 dpc), and a 57% reduction in lung lesions compared with controls. Group 1 (ATCC-VR-2332) also reached complete seroconversion by 21 dpv, whereas Group 3 (P129) showed early but fluctuating seroconversion and Group 4 (attenuated Nebraska) showed delayed and inconsistent seroconversion across sampling points, and Group 5 (control) remained seronegative until after challenge. Group 3 achieved a 63% reduction in lung damage, although with a more variable immune response. In contrast, G1, G4, and the control group showed lung lesions in 100% of animals after challenge. Post-challenge BW gain was significantly greater in G1 and G2 than in the unvaccinated control (one-way ANOVA, P = 0.023; Tukey's HSD, P = 0.039 and P = 0.045, respectively), meanwhile the control group showed a net BW loss after challenge. Overall, under these experimental conditions, Porcimune PRRS MLV was the only vaccine that differed significantly from unvaccinated controls in lung lesions, post-challenge BW gain and ELISA S/P ratio, supporting its protective potential against a heterologous PRRSV challenge.",
  "abstract_shown": true,
  "affiliations": [
    "Departamento de Veterinaria y Zootecnia, Universidad de Guanajuato (UG), Guanajuato, 36500, Mexico.",
    "Centro de Investigación en Biotecnología Aplicada (CIBA), Instituto Politécnico Nacional (IPN), Tlaxcala, 90700, Mexico.",
    "Departamento de Investigación y Desarrollo, Lapisa, La Piedad, Michoacán, 59375, Mexico.",
    "Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, United States.",
    "Centro Nacional de Prevención y Control de Enfermedades (CENAPRECE), Secretaría de Salud México, Mexico City, 11800, Mexico.",
    "Centro de Ciencias Agropecuarias, Universidad Autónoma de Aguascalientes (UA), Aguascalientes, 20131, Mexico."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Carlos A García-Munguía",
      "orcid": "0009-0008-7633-3676"
    },
    {
      "affs": [
        1
      ],
      "name": "María R Robles-López",
      "orcid": "0000-0003-0220-0340"
    },
    {
      "affs": [
        2
      ],
      "name": "Dhamar A Ramírez-Castillo",
      "orcid": "0009-0003-2502-7947"
    },
    {
      "affs": [
        1
      ],
      "name": "Raúl R Robles-de la Torre",
      "orcid": "0000-0001-8696-4326"
    },
    {
      "affs": [
        2
      ],
      "name": "Gloria P Galaviz-Martínez",
      "orcid": "0009-0001-3339-8989"
    },
    {
      "affs": [
        2
      ],
      "name": "José N Aguilar-Toribio",
      "orcid": "0009-0000-5177-7491"
    },
    {
      "affs": [
        2
      ],
      "name": "Alejandro Flores-Montenegro",
      "orcid": "0009-0001-4123-9937"
    },
    {
      "affs": [
        3
      ],
      "name": "Pablo Pineyro",
      "orcid": "0000-0002-0884-7762"
    },
    {
      "affs": [
        4
      ],
      "name": "Fabián Correa-Morales",
      "orcid": "0000-0002-6193-1242"
    },
    {
      "affs": [
        1
      ],
      "name": "Otilio García-Munguía",
      "orcid": "0000-0001-5244-7996"
    },
    {
      "affs": [
        1
      ],
      "name": "Miguel Ángel Plascencia-Espinosa",
      "orcid": "0000-0002-2995-3863"
    },
    {
      "affs": [
        5
      ],
      "name": "Alberto M García-Munguía",
      "orcid": "0000-0001-5450-3197"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8ftfpgf2pyg6g.bib",
  "cited_by": 0,
  "doi": "10.1093/tas/txag176",
  "fulltext_url": "https://europepmc.org/articles/PMC13741231",
  "id": "8ftfpgf2pyg6g",
  "issns": [
    "2573-2102"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997203",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1103|Animal Virus Infections Studies"
    ]
  ],
  "openalex": "W7224130299",
  "pdf_url": "https://europepmc.org/articles/PMC13741231?pdf=render",
  "pmcid": "PMC13741231",
  "pmid": "42997203",
  "published": "2026-10-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8ftfpgf2pyg6g.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997203",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997203"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Virus Infections Studies",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Evaluation of the efficacy of a live attenuated vaccine (porcimune PRRS MLV) against porcine reproductive and respiratory syndrome virus in landrace piglets.",
  "title_text": "Evaluation of the efficacy of a live attenuated vaccine (porcimune PRRS MLV) against porcine reproductive and respiratory syndrome virus in landrace piglets.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/8ftfpgf2pyg6g",
  "venue": "Translational animal science",
  "versions": []
}