{
  "abstract": "Background/Objectives: Real-world colorectal cancer (CRC) treatment is documented across multiple routine hospital data domains, which complicates interpretation of treatment-pattern studies. We characterised medication-documented systemic anticancer treatment patterns in CRC and evaluated the consistency of the routine data sources used to ascertain them. Methods: This retrospective observational study included 1310 encounters from 627 patients with C18—C20 diagnosis codes from 1 March to 30 April 2026. Semicolon-delimited medication entries were normalised to named agents. Patient-level medication-derived treatment patterns were characterised among 54 patients with at least one named antineoplastic documented during the fixed study window, without assuming representativeness of the full CRC-coded cohort; oral prescriptions were analysed separately as complementary evidence. Results: Twenty patients (37.0%) had cytotoxic component(s) only, 20 (37.0%) targeted/immune-checkpoint-inhibitor (ICI) plus cytotoxic components, 12 (22.2%) targeted/ICI components without cytotoxic co-documentation, and 2 (3.7%) other antineoplastic agents only. At the first treatment-documented encounter, 24/54 (44.4%) had at least two named antineoplastic agents co-documented. Thirty-three patients (61.1%) had medication-positive treatment documentation in at least two encounters, and 30/33 (90.9%) had the same documented class set across these encounters. Procedure- and medication-based indicators agreed in 890/891 interpretable encounters (99.89%; Cohen’s kappa 0.9953, 95% CI 0.9839–1.0000). Conclusions: Routine hospital medication data showed heterogeneous medication patterns among CRC-coded patients, frequently with multi-component and repeated documentation. Procedure and medication indicators share a hospital workflow; their near-complete concordance describes internal consistency and cannot exclude joint under-capture or establish clinical accuracy or treatment appropriateness.",
  "abstract_shown": true,
  "affiliations": [
    "Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania",
    "Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania",
    "Research Centre for Gastroenterology and Hepatology,200349, Craiova, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexandru-Marian Vieru"
    },
    {
      "affs": [
        0
      ],
      "name": "Radu Meșină"
    },
    {
      "affs": [
        1
      ],
      "name": "Virginia-Maria Rădulescu",
      "orcid": "0000-0001-9028-7583"
    },
    {
      "affs": [
        1
      ],
      "name": "Emil-Tiberius Trașcă"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Sergiu-Marian Cazacu",
      "orcid": "0000-0001-9623-7683"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Maria-Lorena Mustață",
      "orcid": "0009-0008-6701-0760"
    },
    {
      "affs": [
        1
      ],
      "name": "Daniela-Maria Micu"
    },
    {
      "affs": [
        1
      ],
      "name": "Tudor-Adrian Bălșeanu"
    },
    {
      "affs": [
        1
      ],
      "name": "Petrică Popa"
    },
    {
      "affs": [
        1
      ],
      "name": "Tudorel Ciurea"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8fz7yg8pybhx8.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218486",
  "fulltext_url": null,
  "id": "8fz7yg8pybhx8",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8486",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8fz7yg8pybhx8.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218486",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8486"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Medication-Documented Systemic Anticancer Treatment in Colorectal Cancer: A Single-Centre Routine-Data Study",
  "title_text": "Medication-Documented Systemic Anticancer Treatment in Colorectal Cancer: A Single-Centre Routine-Data Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/8fz7yg8pybhx8",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}