{
  "abstract": "Background\n\nDifferentiation of catecholamine-producing tumours from other adrenal tumours remains difficult. Chromogranin A (CgA) is a marker for catecholamine secretion in the body. An assay for quantification of the CgA epitopes vasostatin and catestatin has been validated for use in dogs but not yet evaluated in dogs with catecholamine-producing tumours. The aims were to evaluate the assays foranalysis of plasma concentrations of the CgA epitopes vasostatin and catestatin in dogs with adrenal tumours and to compare concentrations between catecholamine-producing tumours and adrenocortical tumours in dogs that were subjected to adrenalectomy. Twelve dogs with histopathologically confirmed catecholamine-secreting tumours (eleven pheochromocytomas (PCCs), one extra-adrenal sympathetic paraganglioma (PGL)) and twelve with adrenocortical tumours were included in the study. Plasma concentrations of the CgA epitopes vasostatin and catestatin were determined byradioimmunoassay (RIA), before adrenalectomy in 23 out of 24 dogs and after adrenalectomy in six of the dogs with catecholamine-secreting tumours (five PCC, one PGL). Tumour diagnosis was made by histopathology in all cases.Results\n\nOverall, median plasma concentration of the CgA epitopevasostatin in dogs with catecholamine-secreting tumours was 0.82 nmol/L (interquartile range (IQR) 0.52 to 1.60 nmol/L), which was significantly higher(Wilcoxon rank sum exact test, P= 0.0374) than the vasostatin concentration in adrenocortical tumours (median 0.50; IQR 0.34 to 0.59 nmol/L). A subsetof dogs (5/12) with catecholamine-secreting tumours had elevated plasma vasostatin concentrations preoperatively. After successful surgery, thepreoperatively elevated plasma vasostatin concentrations decreased numerically, however without reaching statistical significance. Catestatin concentrationdid not differ between tumour types.Conclusions\n\nElevated plasma concentration of the CgA epitope vasostatin showed potential as a biomarker for asubset of catecholamine-secreting tumours.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Box 7054, Uppsala, 75007, Sweden.",
    "Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.",
    "Department of Animal Biosciences, Swedish University of Agricultural Sciences (SLU), Box 7023, Uppsala, 75007, Sweden.",
    "Department of Medical Sciences, Uppsala University, Uppsala, 75185, Sweden.",
    "Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Box 7054, Uppsala, 75007, Sweden. Odd.Hoglund@slu.se."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Josefine Prabert",
      "orcid": "0000-0003-2418-8557"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeanette Hanson",
      "orcid": "0000-0001-5596-9538"
    },
    {
      "affs": [
        1
      ],
      "name": "Kumiko Ishigaki",
      "orcid": "0000-0002-7491-2315"
    },
    {
      "affs": [
        1
      ],
      "name": "Kazushi Asano",
      "orcid": "0000-0003-0099-7974"
    },
    {
      "affs": [
        2
      ],
      "name": "Katja Höglund",
      "orcid": "0000-0002-7486-0420"
    },
    {
      "affs": [
        3
      ],
      "name": "Mats Stridsberg",
      "orcid": "0000-0002-9198-4193"
    },
    {
      "affs": [
        4
      ],
      "name": "Odd Viking Höglund",
      "orcid": "0000-0003-0978-836X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8g1skt38f7pbj.bib",
  "cited_by": 0,
  "doi": "10.1186/s12917-026-05996-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13678915",
  "id": "8g1skt38f7pbj",
  "issns": [
    "1746-6148"
  ],
  "landing_url": "https://europepmc.org/article/MED/42897632",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Adrenal and Paraganglionic Tumors"
    ]
  ],
  "openalex": "W7222500421",
  "pdf_url": "https://europepmc.org/articles/PMC13678915?pdf=render",
  "pmcid": "PMC13678915",
  "pmid": "42897632",
  "published": "2026-10-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8g1skt38f7pbj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:33Z",
      "native_id": "MED:42897632",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42897632"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Adrenal and Paraganglionic Tumors",
      "subfield": "surgery"
    }
  ],
  "title": "Use of plasma chromogranin a epitopes vasostatin and catestatin as biomarkers for catecholamine-producing tumours in dogs.",
  "title_text": "Use of plasma chromogranin a epitopes vasostatin and catestatin as biomarkers for catecholamine-producing tumours in dogs.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:33Z",
  "url": "https://research.draconitic.com/paper/8g1skt38f7pbj",
  "venue": "BMC veterinary research",
  "versions": []
}