{
  "abstract": "Introduction\n\nPsychiatric disorders are common among patients with opioid use disorder (OUD). Opioid agonist therapy (OAT) is an effective treatment for OUD, but outcomes for patients with psychiatric comorbidities remain understudied. This study aimed to examine the connections between psychiatric comorbidities and outcomes in individuals undergoing OAT.Methods\n\nWe retrospectively collected data from the Wellbeing Services County of Southwest Finland clinical registry. The cohort included 1,235 patients receiving OAT from January 1, 2004, to April 15, 2021. Patients attending OAT, psychiatric diagnoses, overdoses, and self-harm were identified from the registry data using ICD-10 codes. In cases of death, the register also included the date of death. We analyzed associations between psychiatric comorbidities and outcomes using Cox regression for death and logistic regression for nonfatal overdose and self-harm.Results\n\nWe identified the prevalence of the following psychiatric comorbidities: non-substance use disorder (non-SUD) psychiatric disorders (39.0%), psychosis (17.0%), mood disorders (29.1%), anxiety disorders (26.2%), personality disorders (20.7%), and other SUDs not related to opioids (other SUDs) (61.4%). After adjusting for all covariates, we found an association between alcohol use disorder (AUD) (hazard ratio = 1.54, 95% confidence interval = 1.06-2.22) and a higher risk of death during OAT. Additionally, non-SUD psychiatric disorders (overdose: odds ratio [OR] = 1.64, 1.14-2.36; self-harm: OR = 1.50, 1.03-2.18), psychosis (overdose: OR = 1.89, 1.29-2.79; self-harm: OR = 1.87, 1.26-2.78), and other SUDs (overdose: OR = 2.61, 1.81-3.83; self-harm: OR = 2.56, 1.74-3.82) were associated with higher odds of both overdose and self-harm.Conclusion\n\nThe study emphasizes the need for screening and secondary preventive measures for psychosis and other SUDs (particularly AUD) in OAT settings.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland.",
    "Family and Social Services, Psychiatry, Wellbeing Services County of Päijät-Häme, Lahti, Finland.",
    "Department of Safety, Finnish Institute for Health and Welfare, Forensic Chemistry Unit, Helsinki, Finland.",
    "Western Uusimaa Wellbeing Services County, Mental Health and Substance Abuse Services, Lohja, Finland.",
    "Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland, solnie@utu.fi.",
    "Mental Health and Addiction Services, Wellbeing County of Southwest Finland, Turku, Finland, solnie@utu.fi."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yangyang Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Alexander Denissoff"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Margareeta Häkkinen"
    },
    {
      "affs": [
        0
      ],
      "name": "Lauri Sillanmäki"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Solja Niemelä"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8gdxr070b6xj1.bib",
  "cited_by": 0,
  "doi": "10.1159/ear/acrag001",
  "fulltext_url": "https://europepmc.org/articles/PMC13695521",
  "id": "8gdxr070b6xj1",
  "issns": [
    "1022-6877",
    "1421-9891"
  ],
  "landing_url": "https://europepmc.org/article/MED/42895930",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Opioid Use Disorder Treatment"
    ]
  ],
  "openalex": "W7222923011",
  "pdf_url": "https://karger.com/ear/article-pdf/doi/10.1159/ear/acrag001/4596220/000554949.pdf",
  "pmcid": "PMC13695521",
  "pmid": "42895930",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8gdxr070b6xj1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42895930",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42895930"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Opioid Use Disorder Treatment",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Psychiatric Comorbidities and Risks of Death, Nonfatal Overdose, and Self-Harm in Opioid Agonist Therapy: A Retrospective Cohort Study.",
  "title_text": "Psychiatric Comorbidities and Risks of Death, Nonfatal Overdose, and Self-Harm in Opioid Agonist Therapy: A Retrospective Cohort Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/8gdxr070b6xj1",
  "venue": "European addiction research",
  "versions": []
}