{
  "abstract": "Background\n\nHouse dust mite (HDM) is the predominant indoor allergen in children with allergic rhinitis (AR), but conventional binary reporting obscures both sensitization intensity and component-specific profiles.Methods\n\nThis two-stage retrospective cross-sectional study enrolled 2036 children (1-15 years) with AR. Serum sIgE against 19 allergens was measured by immunoblot (≥0.35 kU/L positive). D. pteronyssinus-positive samples were stratified into six sensitization grades. In Stage 2, 110 HDM-positive children underwent component-resolved diagnostics for Der p 1, Der p 2, Der f 1, Der f 2, Der p 23, and Der p 10.Results\n\nD. pteronyssinus was the most prevalent allergen (43.91%, 894/2036; 95% CI 41.77-46.07%). Boys had higher positivity than girls (46.34% vs 39.50%; OR 1.32, 95% CI 1.10-1.59), but among sensitized children, high-grade sensitization (≥grade 4) was similar between sexes (69.08% vs 66.43%, P=0.427). In cross-sectional analyses, the proportion of grade 6 sensitization (>100 kU/L) increased with age, from 15.00% at age 3 to 25.51% at age 5 and 34.58% at age 6. Component positivity rates were: Der f 1 72.73% (80/110), Der p 1 70.91% (78/110), Der f 2 64.55% (71/110), Der p 2 62.73% (69/110), Der p 23 41.82% (46/110), and Der p 10 11.82% (13/110). Co-sensitization between Der p 1 and Der p 23 occurred in only 53.85% of Der p 1-positive children. Exclusive sensitization to D. farinae (0.91%; 95% CI 0.16-4.97%) or Der p 23 (0.91%; 95% CI 0.16-4.97%) was rare.Conclusion\n\nHDM is the leading allergen in pediatric AR in East China. Cross-sectional analyses identified an age-associated increase in the proportion of high-grade sensitization that was most evident around 5-6 years of age. CRD revealed Der p 23 as a major sensitizing component whose sensitization frequently occurred independently of group 1 allergens. Because clinical allergy phenotypes and AIT outcomes were not assessed, the utility of component-resolved profiles for guiding AIT selection requires prospective validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Laboratory Medicine, Hangzhou Children's Hospital, Hangzhou, Zhejiang, 310014, People's Republic of China.",
    "Department of Laboratory Medicine, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, 310021, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xudong Xu",
      "orcid": "0009-0006-7227-8222"
    },
    {
      "affs": [
        0
      ],
      "name": "Cuiying Ye",
      "orcid": "0009-0002-4711-1544"
    },
    {
      "affs": [
        0
      ],
      "name": "Dong Chen",
      "orcid": "0009-0004-3469-276X"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiangyang Xiao",
      "orcid": "0009-0004-6223-0685"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhichang Wang",
      "orcid": "0009-0003-9070-9776"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinfeng Zhao",
      "orcid": "0009-0002-0777-8547"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8gkqhhds2f57b.bib",
  "cited_by": 0,
  "doi": "10.2147/jaa.s641282",
  "fulltext_url": "https://europepmc.org/articles/PMC13726505",
  "id": "8gkqhhds2f57b",
  "issns": [
    "1178-6965"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974113",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2723|Allergic Rhinitis and Sensitization"
    ]
  ],
  "openalex": "W7224101645",
  "pdf_url": "https://europepmc.org/articles/PMC13726505?pdf=render",
  "pmcid": "PMC13726505",
  "pmid": "42974113",
  "published": "2026-10-29",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/8gkqhhds2f57b.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974113",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974113"
    },
    {
      "first_seen": "2026-11-05T12:22:49Z",
      "native_id": "PMC13726505",
      "source": "pmc",
      "url": "https://doi.org/10.2147/jaa.s641282"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2723|Allergic Rhinitis and Sensitization",
      "subfield": "immunology"
    }
  ],
  "title": "Allergen Spectrum and House Dust Mite Component-Resolved Sensitization Patterns in Children with Allergic Rhinitis: A Two-Stage Study.",
  "title_text": "Allergen Spectrum and House Dust Mite Component-Resolved Sensitization Patterns in Children with Allergic Rhinitis: A Two-Stage Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:26Z",
  "url": "https://research.draconitic.com/paper/8gkqhhds2f57b",
  "venue": "Journal of asthma and allergy",
  "versions": []
}