{
  "abstract": "Importance\n\nTraditional cancer diagnostics in veterinary medicine are limited by invasiveness and insufficient sensitivity for real-time molecular monitoring. This review critically evaluates the clinical applicability of somatic mutation profiling and liquid biopsy technologies to establish an evidence-based, tiered framework for precision oncology in canine patients, with emphasis on veterinary-specific constraints and technology selection.Observations\n\nKey somatic biomarkers demonstrate strong clinical utility: BRAF V595E achieves > 80% diagnostic sensitivity in canine urothelial carcinoma and is detectable non-invasively in urine via droplet digital polymerase chain reaction (ddPCR). The multicenter cancer detection in dogs (CANDiD) study demonstrated circulating tumor DNA-based liquid biopsy achieves 54.7% overall sensitivity and 98.5% specificity, though stage I detection remains critically limited at 16.1%, underscoring the current gap for early-stage screening. Minimal residual disease assessment via allele-specific oligonucleotide-PCR and next-generation sequencing enables detection of molecular relapse 42-168 days before clinical manifestation in canine lymphoma. However, analytical variability across platforms, lack of standardized pipelines, and high cost represent significant barriers to routine veterinary application.Conclusions and relevance\n\nGenomic-guided oncology offers substantial clinical value for canine cancer management yet requires veterinary-specific validation before broad adoption. Targeted sequencing panels currently represent the optimal balance of cost-effectiveness and clinical utility for most veterinary practitioners, while ddPCR is preferred for longitudinal tracking of known mutations. Liquid biopsy cannot serve as a standalone screening tool at present, but functions as a valuable complementary monitoring approach. Continued canine-specific biomarker research and multicenter data sharing are essential prerequisites for integrating precision medicine into routine veterinary care.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Korea.",
    "Institute of Agriculture and Life Sciences, Gyeongsang National University, Jinju 52828, Korea.",
    "College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea.",
    "Royal Animal Medical Center, Seoul 02140, Korea. dvmydh@gmail.com."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Minjeong Kang",
      "orcid": "0000-0001-9145-2050"
    },
    {
      "affs": [
        1
      ],
      "name": "Jaemin Kim",
      "orcid": "0000-0003-1746-2546"
    },
    {
      "affs": [
        2
      ],
      "name": "Jinho Park",
      "orcid": "0000-0001-5235-5717"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "DoHyeon Yu",
      "orcid": "0000-0001-7645-6926"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8grsq2y9eywc2.bib",
  "cited_by": 1,
  "doi": "10.4142/jvs.25370",
  "fulltext_url": "https://europepmc.org/articles/PMC13655552",
  "id": "8grsq2y9eywc2",
  "issns": [
    "1229-845X",
    "1976-555X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42847792",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Veterinary Oncology Research"
    ]
  ],
  "openalex": "W7168415609",
  "pdf_url": "https://europepmc.org/articles/PMC13655552?pdf=render",
  "pmcid": "PMC13655552",
  "pmid": "42847792",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8grsq2y9eywc2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42847792",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42847792"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Veterinary Oncology Research",
      "subfield": "general"
    }
  ],
  "title": "Genomic-guided precision oncology in canine cancer: from comparative genomics to liquid biopsy and molecular monitoring.",
  "title_text": "Genomic-guided precision oncology in canine cancer: from comparative genomics to liquid biopsy and molecular monitoring.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/8grsq2y9eywc2",
  "venue": "Journal of veterinary science",
  "versions": []
}