{
  "abstract": "The bone marrow microenvironment (BME) has a significant effect on bortezomib (BTZ)-based chemotherapy in patients with multiple myeloma (MM). However, how BME components drive effective BTZ-based chemotherapy to facilitate antitumor responses has yet to be fully understood. Using single-cell transcriptome analysis, we discerned a notable increase in the density of tumor-associated IL1B⁺ monocytes (TAMO_IL1B), a CD14⁺ monocyte subcluster, within the optimal responders (OR) group compared with the suboptimal responders (SOR) group. TAMO_IL1B in the OR group had significantly greater effects on the TGF-β signaling pathway. The ligand-receptor pair (THBS1-SDC1) interaction intensity in the THBS1 signaling pathway between TAMO_IL1B and tumor plasma cells (TPC) in the OR group was significantly greater than that in the SOR group. Furthermore, pseudotime trajectory analysis indicated that TAMO_IL1B predominantly occupied late differentiation stages and was associated with a favorable response within the OR group. These findings reveal a previously unrecognized role for TAMO_IL1B in shaping antitumor immunity. The THBS1-SDC1 axis may contribute to interactions between monocytes and plasma cells; however, functional validation is required before any therapeutic implications can be drawn.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. chengtaofanglm@163.com.",
    "Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.",
    "Houston Methodist Research Institute, Houston, TX, USA.",
    "Edibeck Therapeutics Company Limited, Shenzhen, China. yueli7@126.com.",
    "Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. wei_rong001@163.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Taofang Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Huiqun Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Rui Jing"
    },
    {
      "affs": [
        3
      ],
      "name": "Yue Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Rong Wei"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8gsf86db2zyrv.bib",
  "cited_by": 0,
  "doi": "10.1038/s41698-026-01666-w",
  "fulltext_url": "https://europepmc.org/articles/PMC13720119",
  "id": "8gsf86db2zyrv",
  "issns": [
    "2397-768X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957756",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2720|Multiple Myeloma Research and Treatments"
    ]
  ],
  "openalex": "W7224554722",
  "pdf_url": "https://europepmc.org/articles/PMC13720119?pdf=render",
  "pmcid": "PMC13720119",
  "pmid": "42957756",
  "published": "2026-10-28",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/8gsf86db2zyrv.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:36Z",
      "native_id": "MED:42957756",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957756"
    },
    {
      "first_seen": "2026-11-02T12:23:58Z",
      "native_id": "PMC13720119",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41698-026-01666-w"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2720|Multiple Myeloma Research and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Single-cell analysis reveals favorable responses of tumor-associated monocytes to bortezomib-based treatment in multiple myeloma.",
  "title_text": "Single-cell analysis reveals favorable responses of tumor-associated monocytes to bortezomib-based treatment in multiple myeloma.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:03Z",
  "url": "https://research.draconitic.com/paper/8gsf86db2zyrv",
  "venue": "NPJ precision oncology",
  "versions": []
}