{
  "abstract": "Myxobacteria are prolific producers of structurally diverse secondary metabolites and represent a valuable source of anticancer lead compounds. In this study, quinaldic acid (QA) was putatively annotated from a myxobacterial metabolite extract by LC–MS/MS spectral matching and evaluated for its antitumor activity against non-small cell lung cancer (NSCLC) cells. QA inhibited the viability of four tumor cell lines in a concentration-dependent manner, with A549 lung adenocarcinoma cells displaying the highest sensitivity, with an IC50 of 1.07 mM after 24 h of treatment. QA also significantly suppressed clonogenic growth in A549 cells. Network pharmacology analysis suggested that QA may regulate NSCLC-related targets and pathways involved in cell-cycle control, apoptosis, p53, JAK–STAT, and NF-κB signaling. Experimental validation showed that QA induced S-phase accumulation in A549 cells, increasing the S-phase population by 14.70 percentage points at 4 mM. This effect was accompanied by increased cyclin A1 expression and decreased cyclin B1 and CDK1 expression. QA also promoted apoptosis in a concentration-dependent manner, increasing the apoptotic population by 40.40 percentage points at 2 mM. Apoptosis was associated with elevated BAX and caspase-3 expression and reduced BCL-2 expression. These findings suggest that QA suppresses A549 cell growth by inducing S-Phase accumulation and apoptosis, supporting its potential as a myxobacteria-derived anticancer scaffold.",
  "abstract_shown": true,
  "affiliations": [
    "College of Life Sciences, Inner Mongolia Agricultural University, No. Zhaowuda Road, Saihan District, Hohhot 010008, China",
    "College of Science, Inner Mongolia Agricultural University, Hohhot 010008, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Songyuan Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lingmin Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Liangliang Bao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hanwen He"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuting Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Qu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lele Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Huirong Liu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8gsxx4gvtf97e.bib",
  "cited_by": 0,
  "doi": "10.3390/biom16111551",
  "fulltext_url": null,
  "id": "8gsxx4gvtf97e",
  "issns": [
    "2218-273X"
  ],
  "landing_url": "https://www.mdpi.com/2218-273X/16/11/1551",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3005|Bioactive Compounds and Antitumor Agents"
    ]
  ],
  "openalex": "W7223651654",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8gsxx4gvtf97e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:59Z",
      "native_id": "10.3390/biom16111551",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-273X/16/11/1551"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3005|Bioactive Compounds and Antitumor Agents",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Quinaldic Acid Inhibits A549 Lung Cancer Cell Growth Through S-Phase Accumulation and Apoptosis",
  "title_text": "Quinaldic Acid Inhibits A549 Lung Cancer Cell Growth Through S-Phase Accumulation and Apoptosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:59Z",
  "url": "https://research.draconitic.com/paper/8gsxx4gvtf97e",
  "venue": "Biomolecules",
  "versions": []
}