{
  "abstract": "Although vascular development is fundamental during embryogenesis, the developmental basis and tissue interactions underlying anatomical variation in major veins are not fully understood. The renal segment of the inferior vena cava exhibits significant anatomical variations that often affect the safety of retroperitoneal surgery. Using mouse embryos, we show that the renal segment of the inferior vena cava is not primarily dependent on the subcardinal vein as classically proposed, but instead forms from a vascular plexus closely associated with the developing para-aortic ridge. Genetic models further indicate that sympathoadrenal development in the para-aortic ridge contributes to the proper organization and remodeling of this vascular network. This revised developmental framework highlights a sympathoadrenal–vascular coupling as a developmental basis for inferior vena cava formation and thereby challenges classical subcardinal vein-dependent models.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "name": "Aki Murashima",
      "orcid": "0000-0001-6294-9703"
    },
    {
      "name": "Daisuke Matsumaru",
      "orcid": "0000-0002-1832-624X"
    },
    {
      "name": "Takashi Moriguchi"
    },
    {
      "name": "Yuichi Shima"
    },
    {
      "name": "Miki Inoue",
      "orcid": "0000-0003-3581-9852"
    },
    {
      "name": "Chikako Yokoyama",
      "orcid": "0000-0002-9219-8661"
    },
    {
      "name": "Ken-ichirou Morohashi"
    },
    {
      "name": "Yoshiaki Kubota",
      "orcid": "0000-0001-6672-4122"
    },
    {
      "name": "Takatoshi Ueki"
    },
    {
      "name": "Jiro Hitomi"
    },
    {
      "name": "Sumio Isogai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8haw0nmnmsa54.bib",
  "cited_by": 0,
  "doi": "10.1038/s42003-026-11297-3",
  "fulltext_url": null,
  "id": "8haw0nmnmsa54",
  "issns": [
    "2399-3642"
  ],
  "landing_url": "https://www.nature.com/articles/s42003-026-11297-3",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-07",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/8haw0nmnmsa54.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:28Z",
      "native_id": "10.1038/s42003-026-11297-3",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s42003-026-11297-3"
    },
    {
      "first_seen": "2026-11-07T21:20:59Z",
      "native_id": "10.1038/s42003-026-11297-3",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s42003-026-11297-3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:2399-3642",
      "subfield": "general"
    }
  ],
  "title": "The sympathoadrenal contribution to inferior vena cava formation",
  "title_text": "The sympathoadrenal contribution to inferior vena cava formation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T00:20:25Z",
  "url": "https://research.draconitic.com/paper/8haw0nmnmsa54",
  "venue": "Communications Biology",
  "versions": []
}