{
  "abstract": "Background\n\nEndometrial carcinoma (EC) is the most common gynecological malignancy in developed countries and is increasing in incidence in low- and middle-income settings, including Indonesia. Age and parity are well-recognized epidemiological risk factors; however, their differential impact on histopathological tumor subtypes-particularly in older women-remains insufficiently characterized in Southeast Asian populations.Purpose\n\nTo evaluate the associations between patient age and parity with the histopathological subtype of endometrial carcinoma in women treated at a tertiary referral hospital in Indonesia.Patients and methods\n\nA cross-sectional analytic study was conducted using retrospectively collected medical records from 207 patients aged ≥50 years with histopathologically confirmed endometrial carcinoma at Prof. Dr. Margono Soekarjo Regional Public Hospital, Purwokerto, between January and December 2024. Patients with incomplete clinicopathological data were excluded. Age was categorized into 50-60 years and >60 years; parity into nulliparous/primiparous and multiparous (≥2 deliveries). Histopathological subtypes were classified as endometrioid vs non-endometrioid carcinoma. Associations were evaluated using chi-square tests and multivariate logistic regression; statistical significance was defined as p < 0.05, with 95% confidence intervals (CI) reported.Results\n\nOf 207 eligible patients, the majority (92.5%) were aged 50-60 years. Non-endometrioid carcinoma predominated in women aged >60 years (p < 0.001; relative risk [RR] = 19.2; 95% CI: 8.7-42.0). Multiparous patients exhibited a significantly higher prevalence of endometrioid histology (93.8%) compared with nulliparous/primiparous patients (90.6%; p = 0.02; RR = 20.7). On multivariate analysis, both age and parity were predictors of histopathological subtype, with age demonstrating a stronger effect size.Conclusion\n\nAdvanced age (>60 years) and low parity are independently associated with non-endometrioid histopathological subtypes of endometrial carcinoma in an Indonesian tertiary center. These findings underscore the clinical importance of incorporating patient age and reproductive history into risk stratification and surveillance strategies for endometrial cancer.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Hasan Sadikin General Teaching Hospital, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia.",
    "Department of Obstetrics and Gynecology, Prof. Dr Margono Soekarjo Regional Public Hospital, Faculty of Medicine, Jenderal Soedirman University, Banyumas, Central Java, Indonesia."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Raden Fuad Mustaqim"
    },
    {
      "affs": [
        1
      ],
      "name": "Aditiyono Aditiyono"
    },
    {
      "affs": [
        0
      ],
      "name": "Gatot Nyarumenteng Adhipurnawan Winarno",
      "orcid": "0000-0001-8537-5415"
    },
    {
      "affs": [
        0
      ],
      "name": "Mohamad Egatama"
    },
    {
      "affs": [
        0
      ],
      "name": "Prastika Candra Triastuti"
    },
    {
      "affs": [
        0
      ],
      "name": "Laga Cahya Yudha",
      "orcid": "0009-0009-3768-5879"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8hf1z7ngwfnes.bib",
  "cited_by": 0,
  "doi": "10.2147/ijwh.s625423",
  "fulltext_url": "https://europepmc.org/articles/PMC13718319",
  "id": "8hf1z7ngwfnes",
  "issns": [
    "1179-1411"
  ],
  "landing_url": "https://europepmc.org/article/MED/42960134",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2729|Endometrial and Cervical Cancer Treatments"
    ]
  ],
  "openalex": "W7223439954",
  "pdf_url": "https://europepmc.org/articles/PMC13718319?pdf=render",
  "pmcid": "PMC13718319",
  "pmid": "42960134",
  "published": "2026-10-25",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/8hf1z7ngwfnes.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42960134",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42960134"
    },
    {
      "first_seen": "2026-11-02T12:22:22Z",
      "native_id": "PMC13718319",
      "source": "pmc",
      "url": "https://doi.org/10.2147/ijwh.s625423"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Endometrial and Cervical Cancer Treatments",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Advanced Age and Low Parity as Predictors of Non-Endometrioid Histopathological Subtypes in Endometrial Carcinoma: A Cross-Sectional Study in Indonesia.",
  "title_text": "Advanced Age and Low Parity as Predictors of Non-Endometrioid Histopathological Subtypes in Endometrial Carcinoma: A Cross-Sectional Study in Indonesia.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:22Z",
  "url": "https://research.draconitic.com/paper/8hf1z7ngwfnes",
  "venue": "International journal of women's health",
  "versions": []
}