{
  "abstract": "Background\n\nFully automated plasma p-tau217 assays may facilitate clinical implementation of blood-based testing for Alzheimer's disease (AD) amyloid pathology. However, data on assay-specific decision thresholds and clinical utility in East Asian memory-clinic populations remain limited.Methods\n\nWe evaluated plasma Roche p-tau217 in 139 participants from a Taiwanese memory clinic using amyloid PET or CSF biomarkers as reference standards. Diagnostic performance and single- and dual-cutoff decision thresholds were assessed. Head-to-head comparisons with Simoa p-tau217, Roche p-tau181, and neurofilament light chain (NfL) were performed in participants with complete biomarker profiles. Associations with body mass index and renal function were also examined.Results\n\nRoche p-tau217 showed high diagnostic accuracy for amyloid β (Aβ) positivity (AUC 0.973). In the primary threshold-analysis cohort, a dual-cutoff approach using thresholds of 0.225 and 0.336 pg/mL classified 88.1% of participants into definitive negative or positive zones, with an overall percent agreement of 95.0% within these zones. Sensitivity analyses showed similar performance. In participants with complete biomarker profiles, no statistically significant difference in AUC was detected between Roche p-tau217 and Simoa p-tau217, whereas Roche p-tau217 showed significantly higher AUC than p-tau181 and NfL. Lower estimated glomerular filtration rate (eGFR) was independently associated with higher p-tau217 concentrations.Conclusions\n\nFully automated Roche p-tau217 showed high diagnostic performance for identifying Aβ pathology. Cohort-derived dual decision thresholds classified most participants into definitive zones and may support plasma p-tau217-based triage for confirmatory amyloid testing in memory-clinic practice. External validation is required before clinical implementation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, 112201, Taiwan.",
    "School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.",
    "Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan.",
    "Graduate Institute of Medical Sciences, National Defense Medical University, Taipei, 114202, Taiwan.",
    "Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou Dist., Taipei, 112201, Taiwan.",
    "Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Rd., Beitou Dist., Taipei, 112201, Taiwan. hlho5@vghtpe.gov.tw.",
    "Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. hlho5@vghtpe.gov.tw.",
    "Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, 112201, Taiwan. jlfuh@vghtpe.gov.tw.",
    "School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. jlfuh@vghtpe.gov.tw.",
    "Brain Research Center, National Yang Ming Chiao Tung University, Taipei, 112304, Taiwan. jlfuh@vghtpe.gov.tw."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Yung-Shuan Lin",
      "orcid": "0000-0003-3170-5516"
    },
    {
      "affs": [
        0,
        1,
        3
      ],
      "name": "Meng-Ju Tsai"
    },
    {
      "affs": [
        4
      ],
      "name": "Chien-Liang Lai"
    },
    {
      "affs": [
        5,
        6
      ],
      "name": "Hsiang-Ling Ho"
    },
    {
      "affs": [
        7,
        8,
        9
      ],
      "name": "Jong-Ling Fuh",
      "orcid": "0000-0001-9135-3351"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8hyrsb2c8j2hg.bib",
  "cited_by": 0,
  "doi": "10.1007/s00415-026-14193-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13687179",
  "id": "8hyrsb2c8j2hg",
  "issns": [
    "0340-5354",
    "1432-1459"
  ],
  "landing_url": "https://europepmc.org/article/MED/42905283",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7223129889",
  "pdf_url": "https://europepmc.org/articles/PMC13687179?pdf=render",
  "pmcid": "PMC13687179",
  "pmid": "42905283",
  "published": "2026-10-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8hyrsb2c8j2hg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42905283",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42905283"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "Clinical performance and decision thresholds of an automated plasma p-tau217 assay for amyloid pathology in a Taiwanese memory clinic.",
  "title_text": "Clinical performance and decision thresholds of an automated plasma p-tau217 assay for amyloid pathology in a Taiwanese memory clinic.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/8hyrsb2c8j2hg",
  "venue": "Journal of neurology",
  "versions": []
}