{
  "abstract": "In pancreatic ductal adenocarcinoma (PDAC), fibroblast activation leads to excessive secretion of extracellular matrix (ECM) and soluble factors that regulate tumor progression, prompting investigation into endoplasmic reticulum (ER)-resident proteins that may support this activation. We identified FKBP7, a peptidyl-prolyl isomerase in the ER, as overexpressed in PDAC stroma compared to cancer cells, and in patients with favorable prognosis. Analysis of single-cell RNA sequencing databases revealed FKBP7 expression in pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs). When analyzed by immunohistochemistry on PDAC patient tissues, FKBP7 emerged as an early activation marker in the preneoplastic stroma, preceding αSMA expression, and responding to FAK- and TGFβ-induced stiffening and pro-fibrotic programs in PSCs. Functional analyses revealed that FKBP7 knockdown in PSCs enhanced contractility, Rho/FAK signaling, and secretion of pro-inflammatory cytokines as well as remodeling of type I collagen, promoting an activated phenotype and accelerating tumor growth in vivo. Conversely, FKBP7 expression supported a tumor-restraining (i.e. encapsulating) ECM characterized by type IV collagen. Mechanistically, FKBP7 interacts with BiP, and blocking this interaction instead leads to increased PSC secretion of type I collagen. Thus, FKBP7 serves as a novel PSC marker and ER regulator in a complex with BiP of the secretion of specific collagen subtypes, highlighting its potential to mediate ECM normalization and constrain PDAC tumorigenesis.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Christophe Quemerais"
    },
    {
      "name": "Christine Jean"
    },
    {
      "name": "Alexia Brunel"
    },
    {
      "name": "Emilie Decaup"
    },
    {
      "name": "Guillaume Labrousse"
    },
    {
      "name": "Hippolyte Audureau"
    },
    {
      "name": "Jérôme Raffenne"
    },
    {
      "name": "Ismahane Belhabib"
    },
    {
      "name": "Jérôme Cros"
    },
    {
      "name": "Aurélie Perraud"
    },
    {
      "name": "Nelson Dusetti"
    },
    {
      "name": "Remy Nicolle"
    },
    {
      "name": "Muriel Mathonnet"
    },
    {
      "name": "Stéphane Pyronnet"
    },
    {
      "name": "Yvan Martineau"
    },
    {
      "name": "Marjorie Fanjul"
    },
    {
      "name": "Corinne Bousquet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8jc7p453yc8dq.bib",
  "cited_by": 6,
  "doi": "10.1016/j.canlet.2025.217538",
  "fulltext_url": null,
  "id": "8jc7p453yc8dq",
  "issns": [
    "0304-3835"
  ],
  "landing_url": "https://hal.science/hal-05782063v1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.bc"
    ],
    [
      "hal",
      "1.sdv.can"
    ],
    [
      "openalex",
      "2730|Pancreatic and Hepatic Oncology Research"
    ]
  ],
  "openalex": "W4407246281",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-06",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/8jc7p453yc8dq.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "hal-05782063",
      "source": "hal",
      "url": "https://hal.science/hal-05782063v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.bc",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.can",
      "subfield": "oncology"
    }
  ],
  "title": "Unveiling FKBP7 as an early endoplasmic reticulum sentinel in pancreatic stellate cell activation, collagen remodeling and tumor progression",
  "title_text": "Unveiling FKBP7 as an early endoplasmic reticulum sentinel in pancreatic stellate cell activation, collagen remodeling and tumor progression",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/8jc7p453yc8dq",
  "venue": "Cancer Letters",
  "versions": []
}