{
  "abstract": "Background: Multiple rectal neuroendocrine tumors (MR-NETs) are rare. There is no consensus on their characteristics and treatment. We aimed to evaluate the efficacy and safety of endoscopic resection (ER) for MR-NETs.\n\nMethods: We performed a retrospective review of 24 patients with 57 rectal NETs who underwent ER at Zhongshan Hospital, Fudan University. Baseline information, procedure-related characteristics and postoperative outcomes were analyzed.\n\nResults: The mean maximal diameter was 8.2 ± 4.5 mm, with 43 lesions < 10 mm and 14 lesions ≥ 10 mm. Seventeen patients had 2 lesions, 6 patients had 3 lesions and 1 patient had 5 lesions. There were 53 lesions treated by endoscopic submucosal dissection, 2 lesions treated by endoscopic mucosal resection, and 2 lesions treated by endoscopic submucosal excavation. The en bloc resection rate and technical success rate were both 100%. There were no delayed bleeding or perforation. All patients were eventually discharged safely, with a mean post-procedure hospital stay of 1.81 ± 0.48 days. Tumor grade was G1 in 54 (94.7%) lesions and G2 in 3 lesions (5.3%). Positive margins were found in 10 lesions, including 2 lesions (3.5%) with lateral margin involvement, and 8 cases (14.0%) with basal margin involvement. Mean follow-up was 34.96 ± 23.20 months, with only 3 local recurrences which were successfully managed by salvage ER. There were no recurrences in the 10 lesions with positive margins.\n\nConclusions: ER is a safe and effective technique for small MR-NETs. Positive resection margins do not appear to adversely affect the prognosis of small MR-NETs. Salvage ER may be a viable option in recurrent cases.",
  "abstract_shown": true,
  "affiliations": [
    "Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China",
    "Endoscopy Center, Shanghai Geriatric Medical Center, Shanghai, China",
    "Endoscopy Center, Minhang Hospital, Fudan University, Shanghai, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pei-Rong Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zu-Qiang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yan-Fang Tan"
    },
    {
      "affs": [
        2
      ],
      "name": "Zi-Yu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng-Jiang He"
    },
    {
      "affs": [
        0
      ],
      "name": "Quan-Lin Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ping-Hong Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Hu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8jr0csg4bxehm.bib",
  "cited_by": 0,
  "doi": "10.1186/s12876-026-05317-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737705/",
  "id": "8jr0csg4bxehm",
  "issns": [
    "1471-230X"
  ],
  "landing_url": "https://doi.org/10.1186/s12876-026-05317-z",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2730|Neuroendocrine Tumor Research Advances"
    ]
  ],
  "openalex": "W7220747991",
  "pdf_url": "https://link.springer.com/content/pdf/10.1186/s12876-026-05317-z.pdf",
  "pmcid": "PMC13737705",
  "pmid": "42989106",
  "published": "2026-10-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/8jr0csg4bxehm.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:50Z",
      "native_id": "PMC13737705",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12876-026-05317-z"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Neuroendocrine Tumor Research Advances",
      "subfield": "oncology"
    }
  ],
  "title": "The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center",
  "title_text": "The efficacy and safety of endoscopic resection for multiple rectal neuroendocrine tumors: a retrospective cohort study from a tertiary center",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:50Z",
  "url": "https://research.draconitic.com/paper/8jr0csg4bxehm",
  "venue": "BMC Gastroenterology",
  "versions": []
}