{
  "abstract": "Background\n\nLimited data are available on the association between early longitudinal changes in platelet count and mortality.Objective\n\nThis study aimed to compare the early longitudinal changes in platelet count between survivors and non-survivors.Methods\n\nThis was a retrospective multi-center cohort study using data from the eICU Collaborative Research Database. A total of 6,769 patients diagnosed with AMI were included in the study. The analysis employed a Generalized Additive Model (GAM) and a Generalized Additive Mixed Model (GAMM) to compare longitudinal changes in platelet count between survivors and non-survivors.Results\n\nThe ICU 28-day and ICU 7-day all-cause mortality were 6.1% and 4.6%, respectively. During the first 5 days of ICU admission, GAM showed that non-survivors exhibited a significantly greater decline in platelet count than survivors. Specifically, the GAMM results showed that the difference in platelet count between ICU 28-day non-survivors and ICU 28-day survivors increased by an average of 15.4 × 10⁹/L daily (95% Confidence Interval [CI], 14.1 to 16.7; p < 0.001). Similarly, the difference in platelet count between ICU 7-day non-survivors and ICU 7-day survivors increased by an average of 18.0 × 10⁹/L daily (95% CI, 16.1-19.8; p < 0.001).Conclusions\n\nAn early longitudinal decline in platelet count was associated with a poor prognosis in patients with AMI. However, this study is observational, and causality cannot be inferred.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Intensive Care Unit, Quanzhou First Hospital Affiliated to Fujian Medical University, Fujian, China.",
    "Fujian Provincial Key Laboratory of Difficult and Critical Disease Research; Department of Critical Care Medicine, Fuzhou University Affiliated Provincial Hospital, Fujian, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tianlai Lin",
      "orcid": "0000-0003-3252-5090"
    },
    {
      "affs": [
        1
      ],
      "name": "Jingqing Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoling Zeng"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiang Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mouying Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xizhe Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Youli Chen",
      "orcid": "0000-0003-2538-6256"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8jzj3drefhrpy.bib",
  "cited_by": 0,
  "doi": "10.1002/clc.70504",
  "fulltext_url": "https://europepmc.org/articles/PMC13688426",
  "id": "8jzj3drefhrpy",
  "issns": [
    "0160-9289",
    "1932-8737"
  ],
  "landing_url": "https://europepmc.org/article/MED/42910498",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Acute Myocardial Infarction Research"
    ]
  ],
  "openalex": "W7223177024",
  "pdf_url": "https://europepmc.org/articles/PMC13688426?pdf=render",
  "pmcid": "PMC13688426",
  "pmid": "42910498",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8jzj3drefhrpy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910498",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42910498"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study.",
  "title_text": "An Early Longitudinal Decrease in Platelet Count Is Associated With Poor Prognosis in Acute Myocardial Infarction Patients: A Multicenter Retrospective Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/8jzj3drefhrpy",
  "venue": "Clinical cardiology",
  "versions": []
}