{
  "abstract": "Objectives: Klebsiella pneumoniae (Kp) bloodstream infections (BSIs) are a major concern in the Philippines, but local clinical and molecular epidemiologic data are limited.\n\nMethods: We conducted a cross-sectional study at a government hospital in Manila from April 2023 to January 2024, analyzing clinical data with whole genome sequencing of 39 cases.\n\nResults: Most patients were male (mean age 53 years) and had diabetes or malignancy. The in-hospital mortality rate was 38.5%. Extended-spectrum β-lactamase and carbapenemase genes were identified in 41.0% and 33.3% of isolates, respectively, predominantly blaCTX-M-15, blaNDM, and blaKPC. The most frequent sequence type was ST437, followed by ST23, ST101, and ST17. Hypervirulence genes (rmpA/A2, iuc, and iro) were detected in 25.6% of isolates, defining 10 hypervirulent Kp (hvKp) strains, including one carbapenem-resistant hvKp strain carrying blaNDM-7. Compared with classic Kp infections, hvKp infections resulted in higher rates of septic shock and infection-attributable mortality despite having lower multidrug resistance.\n\nConclusion: These findings underscore the high mortality risk from Kp BSIs, driven by antimicrobial resistance and hypervirulence. The detection of hvKp and carbapenem-resistant hvKp is testament to the global spread of this critical priority pathogen.",
  "abstract_shown": true,
  "affiliations": [
    "National Institutes of Health-University of the Philippines Manila, 623 Pedro Gil St. Ermita, Manila, 1000, Philippines",
    "Philippine General Hospital, Taft Ave, Ermita, Manila, 1000, Philippines",
    "Washington University in St. Louis, 660 S. Euclid Ave, St. Louis, MO, 63110, USA",
    "Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan",
    "Toho University, 5 Chome 21-16 Omorinisihi, Ota City, Tokyo, 143-8540, Japan",
    "University of Pittsburgh, 4200 Fifth Ave., Pittsburgh, PA, 15260, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Christian Francisco"
    },
    {
      "affs": [
        0
      ],
      "name": "Angelo dela Tonga"
    },
    {
      "affs": [
        0
      ],
      "name": "Stessi Marie Geganzo"
    },
    {
      "affs": [
        1
      ],
      "name": "Joana Marie Gantuangco"
    },
    {
      "affs": [
        1
      ],
      "name": "Jonnel Poblete"
    },
    {
      "affs": [
        1
      ],
      "name": "Ia Marie Cruz"
    },
    {
      "affs": [
        1
      ],
      "name": "Bryan Santiago"
    },
    {
      "affs": [
        2
      ],
      "name": "Janet S. Lee"
    },
    {
      "affs": [
        3
      ],
      "name": "Tatsunori Oyabu"
    },
    {
      "affs": [
        3
      ],
      "name": "Masahiro Suzuki"
    },
    {
      "affs": [
        4
      ],
      "name": "Sohei Harada"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Yohei Doi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8k1bjhfjn6crc.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijregi.2026.101039",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13742235/",
  "id": "8k1bjhfjn6crc",
  "issns": [
    "2772-7076"
  ],
  "landing_url": "https://doi.org/10.1016/j.ijregi.2026.101039",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Report"
    ],
    [
      "openalex",
      "2726|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7222104018",
  "pdf_url": null,
  "pmcid": "PMC13742235",
  "pmid": "42997507",
  "published": "2026-10-15",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/8k1bjhfjn6crc.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:06Z",
      "native_id": "PMC13742235",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ijregi.2026.101039"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2726|Antibiotic Resistance in Bacteria",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Clinical and molecular profile of Klebsiella pneumoniae bloodstream infections in a national referral hospital in the Philippines",
  "title_text": "Clinical and molecular profile of Klebsiella pneumoniae bloodstream infections in a national referral hospital in the Philippines",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:06Z",
  "url": "https://research.draconitic.com/paper/8k1bjhfjn6crc",
  "venue": "IJID Regions",
  "versions": []
}