{
  "abstract": "Background: Clinical high-risk states for psychosis (CHR-P) are associated with heterogeneous symptomatic and functional outcomes, only one of which is transition to psychosis. Objective: To propose a structured approach to current care needs and longitudinal clinical formulation alongside established syndromic assessment. Methods: This perspective integrates a targeted, non-systematic appraisal of instrument studies, evidence syntheses, longitudinal cohorts, and guidance with an explicitly author-proposed assessment architecture. Supplementary PubMed searches conducted during revision have been reported separately from the original search. Results: The framework retains validated CHR-P interviews as the syndromic anchor and organizes symptoms, functioning, cognition, comorbidity, developmental context, and longitudinal change into descriptive clinical profiles. A minimal clinical dataset is distinguished from optional structured assessments and investigational biological or digital measures. Descriptive profiles document source measures, current burden, change, and uncertainty without numerical weighting. A staged validation program prioritizes reproducibility, feasibility, and functioning, with transition assessed separately. Conclusions: The current framework offers a candidate structure for documenting needs and discussing care priorities; it does not establish prognostic accuracy or treatment benefit. Prospective evaluation is required before profile-based decisions based on this interpretative model can be recommended. A clinically useful approach to CHR-P research may need to move beyond reductionist conversion/non-conversion predictive models toward more calibrated, externally validated paradigms capable of predicting multiple clinically meaningful trajectories.",
  "abstract_shown": true,
  "affiliations": [
    "Discipline of Psychiatry II, Neurosciences Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania",
    "Clinical Department of Psychiatry, Central Military Emergency University Hospital “Dr. Carol Davila”, 010825 Bucharest, Romania",
    "Department of Psychiatry, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania",
    "Psychiatry Clinic, Craiova Clinical Hospital for Neuropsychiatry, 200473 Craiova, Romania",
    "Discipline of Psychiatry I, Neurosciences Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania",
    "9th Department of Psychiatry, “Prof. Dr. Al. Obregia” Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Octavian Vasiliu",
      "orcid": "0000-0001-6345-3478"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Ileana Marinescu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Andrei G. Mangalagiu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Bogdan M. Petrescu"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Adela M. Ciobanu",
      "orcid": "0000-0003-2520-5486"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8k28zqezxh5w2.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207955",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705783/?tool=EBI",
  "id": "8k28zqezxh5w2",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7955",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2738|Schizophrenia research and treatment"
    ]
  ],
  "openalex": "W7221818002",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705783/pdf/?tool=EBI",
  "pmcid": "PMC13705783",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/8k28zqezxh5w2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207955",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7955"
    },
    {
      "first_seen": "2026-10-30T12:21:34Z",
      "native_id": "PMC:PMC13705783",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705783"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Schizophrenia research and treatment",
      "subfield": "psychiatry"
    }
  ],
  "title": "A Clinical Perspective on Multidimensional Assessment of Clinical High-Risk States for Psychosis Beyond Transition Prediction",
  "title_text": "A Clinical Perspective on Multidimensional Assessment of Clinical High-Risk States for Psychosis Beyond Transition Prediction",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:34Z",
  "url": "https://research.draconitic.com/paper/8k28zqezxh5w2",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}