{
  "abstract": "This study describes the synthesis, photophysical characterization, and bioimaging properties of a series of chalcones derived from apocynin, functionalized with electroactive groups such as phenyldimethylamine (1), triphenylamine (2), tetraphenylethylene (3), and pyrene (4). These molecules featured donor−π–acceptor–donor (D−π–A–D) type architectures designed to promote intramolecular charge transfer (ICT) processes and notable emissive properties. Compounds 1 and 2 exhibited a marked aggregation-caused quenching (ACQ) behavior in THF/water mixtures while compounds 3 and 4 showed a marked enhancement of emission upon aggregation (AIE), associated with the restriction of intramolecular motions in the aggregated state. DFT/TD-DFT calculations and electrochemical studies revealed good electronic communications between the electroactive units. Cellular bioimaging studies performed on compounds 1–4 showed that only compounds 1, 2, and 4 are good fluorescent agents exhibiting notable cellular permeability in HEp-2 carcinoma cells. Overall, these findings demonstrate that apocynin α,β-unsaturated systems constitute versatile luminescent platforms with tunable photophysical properties, suitable for applications in cellular bioimaging and the development of remarkable fluorescent materials.",
  "abstract_shown": true,
  "affiliations": [
    "Universidad del Valle , , ,",
    "Universidad Santiago de Cali , , ,",
    "Universidad de Cartagena , , ,",
    "Universidad del Norte , , Km 5 vía Puerto Colombia , ,",
    "Universidad Libre , , Km 5 vía Puerto Colombia , ,",
    "Universidad Metropolitana , , ,",
    "Universidad del Norte , , ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Camila García-Aquite"
    },
    {
      "affs": [
        1
      ],
      "name": "Luis Illicachi"
    },
    {
      "affs": [
        2
      ],
      "name": "Joel José Montalvo Acosta"
    },
    {
      "affs": [
        0
      ],
      "name": "Alejandro Ortiz"
    },
    {
      "affs": [
        3
      ],
      "name": "Homero G. San-Juan-Vergara"
    },
    {
      "affs": [
        4
      ],
      "name": "Juan D. Rodríguez"
    },
    {
      "affs": [
        5
      ],
      "name": "Walter A. Martínez-De-La-Rosa"
    },
    {
      "affs": [
        6
      ],
      "name": "Daniel Insuasty",
      "orcid": "0000-0001-9662-9505"
    },
    {
      "affs": [
        0
      ],
      "name": "Alberto Insuasty",
      "orcid": "0000-0002-9236-5116"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8kdgzn0sf3dgw.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c09229",
  "fulltext_url": null,
  "id": "8kdgzn0sf3dgw",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09229/5458095/Synthesis-and-Photophysical-Properties-of",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Luminescence and Fluorescent Materials"
    ]
  ],
  "openalex": "W7223707927",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c09229",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/8kdgzn0sf3dgw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:40Z",
      "native_id": "10.1021/acsomega.6c09229",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09229/5458095/Synthesis-and-Photophysical-Properties-of"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Luminescence and Fluorescent Materials",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Synthesis and Photophysical Properties of Electroactive Apocynin Derivatives as Potential Luminogens and Cellular Bioimaging Agents",
  "title_text": "Synthesis and Photophysical Properties of Electroactive Apocynin Derivatives as Potential Luminogens and Cellular Bioimaging Agents",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:40Z",
  "url": "https://research.draconitic.com/paper/8kdgzn0sf3dgw",
  "venue": "ACS Omega",
  "versions": []
}