{
  "abstract": "Severe complications after radical esophagectomy remain a major clinical concern, highlighting the need for early postoperative risk stratification. Existing prediction models rely largely on preoperative factors, and models incorporating early postoperative inflammatory biomarkers to predict severe complications remain limited. This study aimed to develop and internally validate a nomogram integrating baseline characteristics and postoperative day (POD) 1 inflammatory biomarkers to predict severe postoperative complications after radical esophagectomy. Clinical data from 606 consecutive patients (2019-2025) were analyzed. Severe complications were defined as Thoracic Morbidity and Mortality (TM&M) grade ≥ III within 30 days after surgery. Candidate predictors, measured at baseline and from venous blood collected at 06:00 AM on POD 1, included demographics, surgical variables, and inflammatory biomarkers. Least absolute shrinkage and selection operator (LASSO) regression with 10-fold cross-validation was embedded within a 1,000-bootstrap internal validation framework to avoid data leakage, followed by multivariable logistic regression. Severe complications occurred in 178 patients (29.4%). Age [adjusted odds ratio (OR) =1.04], operative time (OR =1.04 per 10-min increase), and non-middle tumor location (OR =1.58) were independent predictors (all P<0.05). Female sex (OR =0.60), neoadjuvant therapy (OR =0.52), and POD 1 lymphocyte-to-monocyte ratio (D1-LMR, OR =0.76) were protective factors. The nomogram yielded an apparent AUC of 0.685 (95% confidence interval: 0.635-0.735) and a bootstrap optimism-corrected AUC of 0.672. At the optimal cutoff of 0.28 determined by the Youden index, sensitivity was 68.5%, specificity 63.4%, positive predictive value 45.2%, and negative predictive value 82.1%. Calibration was excellent (calibration slope =0.942, intercept =0.018, Brier score =0.184). Adding D1-LMR significantly improved predictive performance over baseline clinical models (ΔAUC =0.034, net reclassification improvement =0.158, P=0.008). Decision curve analysis confirmed positive net clinical benefits across threshold probabilities of 2-45%. Integrating baseline features and D1-LMR, this nomogram provides an exploratory early risk-stratification tool on POD 1 to optimize perioperative management and intensive care unit resource allocation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiothoracic Surgery, Affiliated Hospital of Putian University, Putian, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Qiuxia Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Xunlin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiang Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xianlin Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Pengfei Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8kqqheemwsrhs.bib",
  "cited_by": 0,
  "doi": "10.21037/jtd-2026-1418",
  "fulltext_url": "https://europepmc.org/articles/PMC13740761",
  "id": "8kqqheemwsrhs",
  "issns": [
    "2072-1439",
    "2077-6624"
  ],
  "landing_url": "https://europepmc.org/article/MED/42996693",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Esophageal Cancer Research and Treatment"
    ]
  ],
  "openalex": "W7224090485",
  "pdf_url": "https://europepmc.org/articles/PMC13740761?pdf=render",
  "pmcid": "PMC13740761",
  "pmid": "42996693",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8kqqheemwsrhs.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:41Z",
      "native_id": "MED:42996693",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42996693"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Esophageal Cancer Research and Treatment",
      "subfield": "surgery"
    }
  ],
  "title": "Development and internal validation of a prediction model for severe postoperative complications (Thoracic Morbidity and Mortality Grade ≥ III) after radical esophagectomy.",
  "title_text": "Development and internal validation of a prediction model for severe postoperative complications (Thoracic Morbidity and Mortality Grade ≥ III) after radical esophagectomy.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:41Z",
  "url": "https://research.draconitic.com/paper/8kqqheemwsrhs",
  "venue": "Journal of thoracic disease",
  "versions": []
}