{
  "abstract": "Genomic studies at single-cell resolution have implicated multiple cell types associated with clinical and pathological traits in Alzheimer’s Disease (AD), but have not examined common features across broad, multi-ethnic populations, and across multiple regions. To bridge this gap, we performed single-nucleus RNA-seq and ATAC-seq profiling of cortical and subcortical brain regions from post-mortem samples across Non-Latin White, African American, and Latin donors (the latter of any race). Using discrete and continuous dissection of molecular programs, we elucidate cell-type-specific glial and neuronal signatures associated with AD across multiple population groups. Notably, we found that multiple microglial ( GPNMB +, CD74 +, and CR1 + subgroups) and astrocyte ( SERPINH1 + and WIF1 + subgroups) signatures are associated with worse clinical and pathological phenotypes across all three population groups. We also report continuous gene expression factors in oligodendrocytes that are not captured by discrete clusters, yet still show strong associations with disease phenotypes. Finally, we observe these discrete cellular identities and continuous gene programs separate cognitively impaired donors into 6 molecularly distinct subgroups that span racial and ethnic population groups. Overall, our study identifies key cell types and gene programs implicated in AD that are shared across population groups, and provides an initial data set that underscores how representative sampling can capture conserved signatures as well as disease heterogeneity, leading to better prioritization of key cell types for further investigation.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA",
    "Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA",
    "Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA",
    "Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA. vm2545@cumc.columbia.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 26,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Tain Luquez",
      "orcid": "0009-0006-6043-6393"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonathan Algoo"
    },
    {
      "affs": [
        0
      ],
      "name": "Rebecca Chiu",
      "orcid": "0009-0007-5833-8521"
    },
    {
      "affs": [
        0
      ],
      "name": "Jason A. Mares",
      "orcid": "0009-0009-4343-0530"
    },
    {
      "affs": [
        0
      ],
      "name": "Archana Yadav",
      "orcid": "0000-0002-4255-9860"
    },
    {
      "affs": [
        1
      ],
      "name": "Matti Lam",
      "orcid": "0000-0002-1853-4209"
    },
    {
      "affs": [
        0
      ],
      "name": "Pallavi Gaur",
      "orcid": "0000-0002-0286-1950"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaoying Lai"
    },
    {
      "affs": [
        0
      ],
      "name": "Dylan I. Lee",
      "orcid": "0000-0002-0349-6131"
    },
    {
      "affs": [
        0
      ],
      "name": "Fahad Paryani",
      "orcid": "0000-0003-1418-1386"
    },
    {
      "affs": [
        0
      ],
      "name": "Rafe Batchelor"
    },
    {
      "affs": [
        0
      ],
      "name": "I Belli",
      "orcid": "0009-0001-0900-2454"
    },
    {
      "affs": [
        0
      ],
      "name": "Jordan A. Henry"
    },
    {
      "affs": [
        0
      ],
      "name": "Bat Hoter-Ishay",
      "orcid": "0009-0007-8069-264X"
    },
    {
      "affs": [
        0
      ],
      "name": "Courteney Mattison",
      "orcid": "0009-0004-6241-7837"
    },
    {
      "affs": [
        0
      ],
      "name": "Lindsey A. Starr",
      "orcid": "0009-0000-1261-8703"
    },
    {
      "affs": [
        0
      ],
      "name": "Tsering Lama"
    },
    {
      "affs": [
        0
      ],
      "name": "Berke Karaahmet",
      "orcid": "0000-0003-2228-4967"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenqing Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Philip L. De Jager",
      "orcid": "0000-0002-8057-2505"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariko F. Taga",
      "orcid": "0000-0002-5791-2348"
    },
    {
      "affs": [
        1
      ],
      "name": "Lisa Laverne Barnes",
      "orcid": "0000-0002-0072-9817"
    },
    {
      "affs": [
        2,
        1
      ],
      "name": "David X. Márquez",
      "orcid": "0000-0001-8903-4941"
    },
    {
      "affs": [
        1
      ],
      "name": "David A. A Bennett",
      "orcid": "0000-0003-3689-554X"
    },
    {
      "affs": [
        0
      ],
      "name": "Ya Zhang",
      "orcid": "0000-0001-9060-3777"
    },
    {
      "affs": [
        3
      ],
      "name": "Vilas Menon",
      "orcid": "0000-0002-4096-8601"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8mhdy54jsdz0s.bib",
  "cited_by": 11,
  "doi": "10.1038/s41586-026-10793-0",
  "fulltext_url": null,
  "id": "8mhdy54jsdz0s",
  "issns": [
    "0028-0836",
    "1476-4687"
  ],
  "landing_url": "https://doi.org/10.1038/s41586-026-10793-0",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
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  "pdf_url": "https://www.nature.com/articles/s41586-026-10793-0.pdf",
  "pmcid": "PMC12204241",
  "pmid": "40584839",
  "published": "2026-07-15",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/8mhdy54jsdz0s.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:07Z",
      "native_id": "W7168403495",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41586-026-10793-0"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Cell-type signatures of Alzheimer’s disease shared across population groups",
  "title_text": "Cell-type signatures of Alzheimer’s disease shared across population groups",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:07Z",
  "url": "https://research.draconitic.com/paper/8mhdy54jsdz0s",
  "venue": "Nature",
  "versions": []
}