{
  "abstract": "This study demonstrates that FLASH radiotherapy reduces oral mucositis in both wild-type and Fanca -deficient mice. At the cellular level, FLASH attenuated radiation-induced inflammation in the tongue relative to conventional irradiation in both genotypes, indicating that FLASH mitigates inflammatory processes associated with oral mucositis. Collectively, these findings support the potential of FLASH radiotherapy to reduce radiation-induced oral mucositis in the context of Fanca deficiency and the Fanconi anemia genomic background.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America",
    "Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America; Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America",
    "Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, United States of America",
    "Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, United States of America",
    "Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, United States of America; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, 94305, United States of America",
    "Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Phoebe Loo"
    },
    {
      "affs": [
        1
      ],
      "name": "Margaret Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Man Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Stavros Melemenidis"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph B. Schulz"
    },
    {
      "affs": [
        0
      ],
      "name": "Dixin Chen"
    },
    {
      "affs": [
        2
      ],
      "name": "Lucy Whitmore"
    },
    {
      "affs": [
        0
      ],
      "name": "Sara Richter"
    },
    {
      "affs": [
        2
      ],
      "name": "Frederick M. Dirbas"
    },
    {
      "affs": [
        3
      ],
      "name": "Kerriann M. Casey"
    },
    {
      "affs": [
        4
      ],
      "name": "Edward E. Graves"
    },
    {
      "affs": [
        5
      ],
      "name": "Michael W. Epperly"
    },
    {
      "affs": [
        5
      ],
      "name": "Joel Greenberger"
    },
    {
      "name": "Billy W. Loo, Jr."
    },
    {
      "name": "Erinn B. Rankin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8mmbdmr7wwmp6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ctro.2026.101334",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2405630826002296",
  "id": "8mmbdmr7wwmp6",
  "issns": [
    "2405-6308"
  ],
  "landing_url": "https://doi.org/10.1016/j.ctro.2026.101334",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research Article"
    ],
    [
      "lcc",
      "R895-920"
    ],
    [
      "lcc",
      "RC254-282"
    ],
    [
      "openalex",
      "2740|Oral health in cancer treatment"
    ]
  ],
  "openalex": "W7223267430",
  "pdf_url": "https://www.ctro.science/article/S2405-6308(26)00229-6/pdf",
  "pmcid": "PMC13721873",
  "pmid": "42964716",
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/8mmbdmr7wwmp6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:23Z",
      "native_id": "cbb772d95c5749509bb56389900f9fd4",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ctro.2026.101334"
    },
    {
      "first_seen": "2026-10-31T12:21:37Z",
      "native_id": "PMC:PMC13721873",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13721873"
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    {
      "first_seen": "2026-11-03T12:22:29Z",
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      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ctro.2026.101334"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia",
  "title_text": "FLASH reduces radiation-induced oral mucositis in a mouse model of Fanconi anemia",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:29Z",
  "url": "https://research.draconitic.com/paper/8mmbdmr7wwmp6",
  "venue": "Clinical and Translational Radiation Oncology",
  "versions": []
}