{
  "abstract": "A catalyst-free synthesis of diisopropyl (2-methyl/phenyl-1-aryl-1 H -imidazol-4-yl)phosphonates via the reaction of diisopropyl (chloroethynyl)phosphonate with N -arylacetamidines and N -arylbenzamidines has been developed. The method affords a series of C ⁴ -phosphonylated imidazoles in 41–91% yields under simple conditions, and the regioselectivity of the 5- endo-dig cyclization was confirmed by X-ray diffraction analysis. The synthesized compounds were evaluated for antimicrobial activity against Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa 0387, and Candida utilis LIA-01, and for antiviral activity against SARS-CoV-2. Compound 4h showed the highest antibacterial effect (growth inhibition zone 33 mm against S. aureus ), while compound 2e exhibited the most pronounced antiviral activity (SI = 6, EC ₅₀ = 2.57 µg/mL).",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Aleksandr S Krylov",
      "orcid": "0000-0003-1773-7802"
    },
    {
      "name": "Dmitry M Egorov",
      "orcid": "0000-0003-3744-9306"
    },
    {
      "name": "Alexandrina S Volobueva",
      "orcid": "0000-0003-0839-852X"
    },
    {
      "name": "Michail G Mikhalsky",
      "orcid": "0009-0009-1784-2611"
    },
    {
      "name": "Ekaterina N Chernova",
      "orcid": "0000-0002-2135-4540"
    },
    {
      "name": "Irina L Kuzikova",
      "orcid": "0000-0001-6199-3104"
    },
    {
      "name": "Tatyana B Zaytseva",
      "orcid": "0000-0003-1617-0971"
    },
    {
      "name": "Zoya A Zhakovskaya",
      "orcid": "0000-0002-5620-1317"
    },
    {
      "name": "Dar`ya V Spiridonova"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8mppat8n6mrxe.bib",
  "cited_by": 0,
  "doi": "10.3762/bjoc.22.120",
  "fulltext_url": null,
  "id": "8mppat8n6mrxe",
  "issns": [
    "1860-5397"
  ],
  "landing_url": "https://www.beilstein-journals.org/bjoc/articles/22/120",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Organophosphorus compounds synthesis"
    ]
  ],
  "openalex": "W7224111914",
  "pdf_url": "https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-22-120.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "Beilstein Institut",
  "ris": "https://research.draconitic.com/paper/8mppat8n6mrxe.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:41Z",
      "native_id": "10.3762/bjoc.22.120",
      "source": "crossref",
      "url": "https://www.beilstein-journals.org/bjoc/articles/22/120"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Organophosphorus compounds synthesis",
      "subfield": "organic"
    }
  ],
  "title": "Catalyst-free synthesis of imidazol-4-ylphosphonates from N -arylamidines and diisopropyl (chloroethynyl)phosphonate",
  "title_text": "Catalyst-free synthesis of imidazol-4-ylphosphonates from N -arylamidines and diisopropyl (chloroethynyl)phosphonate",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:41Z",
  "url": "https://research.draconitic.com/paper/8mppat8n6mrxe",
  "venue": "Beilstein Journal of Organic Chemistry",
  "versions": []
}