{
  "abstract": "Acrolein (ACR), a highly reactive α,β-unsaturated carbonyl compound generated during thermal food processing and lipid peroxidation, contributes to carbonyl stress and oxidative protein modification. In this study, a reaction-guided UHPLC-DAD-HRMS/MS strategy was developed to screen natural ACR scavengers from Anoectochilus roxburghii (A. roxburghii). Eight major ACR-reactive compounds were identified, and narcissoside (NAR) was selected for further validation due to its relatively high abundance and confirmed ACR reactivity. NAR directly trapped ACR in vitro through mono-, di-, and tri-adduct formation, while in vivo fecal analysis suggested that its metabolite isorhamnetin (ISO) contributed to ACR trapping. NAR also attenuated protein modification in ACR-BSA, MGO-BSA, Glu-BSA, and Fru-BSA models. Furthermore, low-dose subacute ACR exposure showed that NAR and ISO improved serum carbonyl stress, oxidative stress, and inflammatory markers. These findings identify NAR as a representative ACR-trapping constituent of A. roxburghii.",
  "abstract_shown": true,
  "affiliations": [
    "Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, The State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China.",
    "Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Guo Dong Zhuang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yong Pei Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Long Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hang Hong Lo"
    },
    {
      "affs": [
        0
      ],
      "name": "Lin Lin Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao Yun Yun"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Hui Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Cai Ren Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Miao Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Meng Han Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhi Kang Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Vincent Kam Wai Wong"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Betty Yuen Kwan Law"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8n0dj38cnw950.bib",
  "cited_by": 0,
  "doi": "10.1016/j.fochx.2026.104585",
  "fulltext_url": "https://europepmc.org/articles/PMC13677956",
  "id": "8n0dj38cnw950",
  "issns": [
    "2590-1575"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898581",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2704|Phytochemicals and Antioxidant Activities"
    ]
  ],
  "openalex": "W7220848806",
  "pdf_url": "https://europepmc.org/articles/PMC13677956?pdf=render",
  "pmcid": "PMC13677956",
  "pmid": "42898581",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/8n0dj38cnw950.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898581",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898581"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2704|Phytochemicals and Antioxidant Activities",
      "subfield": "general"
    }
  ],
  "title": "Rapid identification of acrolein scavengers from Anoectochilus roxburghii and evaluation of their representative antiglycation and antioxidant activities.",
  "title_text": "Rapid identification of acrolein scavengers from Anoectochilus roxburghii and evaluation of their representative antiglycation and antioxidant activities.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/8n0dj38cnw950",
  "venue": "Food chemistry: X",
  "versions": []
}