{
  "abstract": "Background\n\nThe discrepancies in clinicopathologic characteristics and prognosis between invasive mucinous adenocarcinoma (IMA) and nonmucinous lung adenocarcinoma with a mucin-laden feature (MNLA) remain unclear.Methods\n\nData were collected retospectively for 978 consecutive patients with IMA/MNLA who underwent surgical resection between October 2017 and December 2019. Survival outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test. The adjusted hazard ratio (aHR) with 95% confidence interval (CI) of the prognosticator was calculated using a multivariable Cox proportional hazards model.Results\n\nPure IMA was associated with a higher prevalence of KRAS mutation (51.5%), while MNLA was associated with higher prevalences of EGFR mutation (40.4%) and EML4-ALK rearrangement (19.1%). Regarding prognosis, compared to patients with pure IMA, patients with MNLA or mixed IMA had worse disease-free survival (MNLA: aHR, 2.620, 95% CI, 1.690-4.061; mixed IMA: aHR, 3.458, 95% CI, 1.704-7.016) and overall survival (MNLA: aHR, 2.229, 95% CI, 1.185-4.193; mixed IMA: aHR, 1.723, 95% CI, 0.632-4.698). Among patients who experienced recurrence, those with pure IMA had a higher incidence of intrathoracic-only recurrence compared to those with MNLA (80.8% vs 39.6%), demonstrating that extrathoracic-only recurrence was more prevalent in MNLA (35.1% vs 7.3%). The recurrence pattern of mixed IMA was different from that of pure IMA (pure IMA vs mixed IMA: intrathoracic-only, 80.8% vs 50.0%; both intrathoracic and extrathoracic, 11.5% vs 40.0%).Conclusions\n\nAlthough MNLA, pure IMA, and mixed IMA have consistent mucin-laden features, they appear to exhibit differences in prognosis, clinicopathologic characteristics, and molecular profiles.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.",
    "Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.",
    "Clinical Research Unit, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.",
    "Department of Thoracic Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.",
    "Department of Pathology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Fujun Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ke Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhaoxun Li"
    },
    {
      "affs": [
        2
      ],
      "name": "Aijun You"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Zhen Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yimu Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Mengxing Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Dongliang Bian"
    },
    {
      "affs": [
        4
      ],
      "name": "Junhong Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Gening Jiang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8n3rpbbbaysmf.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xjon.2026.101964",
  "fulltext_url": "https://europepmc.org/articles/PMC13711208",
  "id": "8n3rpbbbaysmf",
  "issns": [
    "2666-2736"
  ],
  "landing_url": "https://europepmc.org/article/MED/42948083",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Thoracic: Lung Cancer"
    ],
    [
      "openalex",
      "2740|Lung Cancer Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7168302713",
  "pdf_url": "https://europepmc.org/articles/PMC13711208?pdf=render",
  "pmcid": "PMC13711208",
  "pmid": "42948083",
  "published": "2026-07-14",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/8n3rpbbbaysmf.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:36Z",
      "native_id": "MED:42948083",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42948083"
    },
    {
      "first_seen": "2026-10-31T12:22:01Z",
      "native_id": "PMC13711208",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.xjon.2026.101964"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Lung Cancer Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Prognostic and clinicopathologic divergence in pulmonary mucinous adenocarcinoma versus nonmucinous adenocarcinoma with a mucin-laden feature.",
  "title_text": "Prognostic and clinicopathologic divergence in pulmonary mucinous adenocarcinoma versus nonmucinous adenocarcinoma with a mucin-laden feature.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:22:01Z",
  "url": "https://research.draconitic.com/paper/8n3rpbbbaysmf",
  "venue": "JTCVS open",
  "versions": []
}