{
  "abstract": "Acute kidney injury (AKI) is a complex and heterogeneous clinical syndrome associated with substantial short- and long-term morbidity and mortality. AKI outcomes are strongly influenced by severity, duration, and recovery trajectory, with persistent AKI conferring a worse prognosis and higher risk of progression to chronic kidney disease. Early AKI detection is limited by the impediments of traditional functional criteria based on serum creatinine and urine output. Stress and damage biomarkers have demonstrated promise for early identification of subclinical AKI and for assessing risk of progression before a functional decline becomes apparent. Preventive strategies remain the foundation of AKI management. The Kidney Disease Improving Global Outcomes AKI care bundle, comprising haemodynamic optimization, close monitoring of kidney function parameters, and avoidance of nephrotoxins and hyperglycaemia, has demonstrated the strongest evidence-based approach for preventing AKI, especially when stress is early identified by biomarkers. Evidence for adjunctive interventions, including remote ischaemic preconditioning and selected pharmacological agents, remains inconsistent and context-dependent. Current evidence supports a paradigm shift towards earlier risk identification, biomarker-guided stratification, and early proactive implementation of targeted preventive strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Munster, Muenster, Germany.",
    "Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Melanie Meersch-Dini"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael Joannidis"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8na1b7zhqvvv1.bib",
  "cited_by": 0,
  "doi": "10.1093/ckj/sfag228",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716672/?tool=EBI",
  "id": "8na1b7zhqvvv1",
  "issns": [
    "2048-8505",
    "2048-8513"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13716672",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00340"
    ],
    [
      "heading",
      "CKJ Review"
    ],
    [
      "openalex",
      "2727|Acute Kidney Injury Research"
    ]
  ],
  "openalex": "W7168365911",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13716672/pdf/?tool=EBI",
  "pmcid": "PMC13716672",
  "pmid": "42959210",
  "published": "2026-07-15",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/8na1b7zhqvvv1.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:39Z",
      "native_id": "PMC:PMC13716672",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13716672"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959210",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959210"
    },
    {
      "first_seen": "2026-11-01T12:23:55Z",
      "native_id": "PMC13716672",
      "source": "pmc",
      "url": "https://doi.org/10.1093/ckj/sfag228"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Acute Kidney Injury Research",
      "subfield": "general"
    }
  ],
  "title": "Preventing acute kidney injury in high-risk patients",
  "title_text": "Preventing acute kidney injury in high-risk patients",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:09Z",
  "url": "https://research.draconitic.com/paper/8na1b7zhqvvv1",
  "venue": "Clinical kidney journal",
  "versions": []
}