{
  "abstract": "Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging cause of invasive infection, but clinical relevance of a 5-biomarker genotypic definition remains unclear. We analyzed 207 episodes of K. pneumoniae bloodstream infection at a tertiary hospital in Japan during 2022–2024. We defined hvKp by PCR detection of all 5 biomarkers: rmpA, rmpA2, iucA, iroB, and peg-344. Overall, hvKp accounted for 14% (28/207) of episodes. Abscess complications occurred in 61% (17/28) of hvKp episodes and 13% (23/179) of classical K. pneumoniae episodes. hvKp case-patients had longer median hospitalization (28 vs. 14 days) and duration of antimicrobial drug treatment (43 vs. 14 days) than those with classical K. pneumoniae. Most (9/10) sequence type 23 hvKp episodes involved abscesses. Short-read whole-genome sequencing detected CTX-M–type extended-spectrum β-lactamase genes in 11% (3/28) of hvKp isolates, representing 1.4% (3/207) of all K. pneumoniae episodes. The 5-biomarker definition delineated a clinically distinct subgroup, demonstrating its value for genomic surveillance of emerging hvKp.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Naoki Watanabe"
    },
    {
      "name": "Tomohisa Watari"
    },
    {
      "name": "Yoshihito Otsuka"
    },
    {
      "name": "Tomoh Matsumiya"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/8nc4f5121dzsz.bib",
  "cited_by": 0,
  "doi": "10.3201/eid3211.260825",
  "fulltext_url": "https://wwwnc.cdc.gov/eid/article/32/11/26-0825_article",
  "id": "8nc4f5121dzsz",
  "issns": [
    "1080-6040",
    "1080-6059"
  ],
  "landing_url": "https://doi.org/10.3201/eid3211.260825",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "lcc",
      "R"
    ],
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "1313|Antibiotic Resistance in Bacteria"
    ]
  ],
  "openalex": "W7221821893",
  "pdf_url": null,
  "pmcid": "PMC13715868",
  "pmid": "42912384",
  "published": "2026-10-30",
  "publisher": "Centers for Disease Control and Prevention",
  "ris": "https://research.draconitic.com/paper/8nc4f5121dzsz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:08Z",
      "native_id": "900c59f0738c46b2b703038a7f2a5e71",
      "source": "doaj",
      "url": "https://doi.org/10.3201/eid3211.260825"
    },
    {
      "first_seen": "2026-11-01T12:23:03Z",
      "native_id": "PMC13715868",
      "source": "pmc",
      "url": "https://doi.org/10.3201/eid3211.260825"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC109-216",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Five-Biomarker Definition for Hypervirulent Klebsiella pneumoniae Bloodstream Infection and Abscess Complications, Japan, 2022–2024",
  "title_text": "Five-Biomarker Definition for Hypervirulent Klebsiella pneumoniae Bloodstream Infection and Abscess Complications, Japan, 2022–2024",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:17Z",
  "url": "https://research.draconitic.com/paper/8nc4f5121dzsz",
  "venue": "Emerging Infectious Diseases",
  "versions": []
}